Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol

Alexander M. Khenkin, Ronny Neumann

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.

Original languageEnglish
Pages (from-to)4090-4092
Number of pages3
JournalAngewandte Chemie - International Edition
Volume39
Issue number22
DOIs
Publication statusPublished - Nov 17 2000

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Keywords

  • Bioorganic chemistry
  • Enzyme catalysis
  • Mutagenesis
  • Steroids
  • Terpenoids

ASJC Scopus subject areas

  • Chemistry(all)

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