A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - Nov 17 2000|
- Bioorganic chemistry
- Enzyme catalysis
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