Oxygen-evolving complex of Photosystem II: An analysis of second-shell residues and hydrogen-bonding networks

Leslie Vogt, David J. Vinyard, Sahr Khan, Gary W. Brudvig

Research output: Contribution to journalReview articlepeer-review

66 Citations (Scopus)

Abstract

The oxygen-evolving complex (OEC) is a Mn4O5Ca cluster embedded in the Photosystem II (PSII) protein complex. As the site of water oxidation, the OEC is connected to the lumen by channels that conduct water, oxygen, and/or protons during the catalytic cycle. The hydrogen-bond networks found in these channels also serve to stabilize the oxidized intermediates, known as the S states. We review recent developments in characterizing these networks via protein mutations, molecular inhibitors, and computational modeling. On the basis of these results, we highlight regions of the PSII protein in which changes have indirect effects on the S1, S2, and S3 oxidation states of the OEC while still allowing photosynthetic activity.

Original languageEnglish
Pages (from-to)152?158-158
JournalCurrent Opinion in Chemical Biology
Volume25
DOIs
Publication statusPublished - Apr 1 2015

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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