Abstract
Erectile dysfunction (ED) has high impact on quality of life in prostatectomy, diabetic and aging patients. An underlying mechanism is cavernous nerve (CN) injury, which causes ED in up to 80% of prostatectomy patients. We examine how sonic hedgehog (SHH) treatment with innovative peptide amphiphile nanofiber hydrogels (PA), promotes CN regeneration after injury. SHH and its receptors patched (PTCH1) and smoothened (SMO) are localized in PG neurons and glia. SMO undergoes anterograde transport to signal to downstream targets. With crush injury, PG neurons degenerate and undergo apoptosis. SHH protein decreases, SMO localization changes to the neuronal cell surface, and anterograde transport stops. With SHH treatment SHH is taken up at the injury site and undergoes retrograde transport to PG neurons, allowing SMO transport to occur, and neurons remain intact. SHH treatment prevents neuronal degeneration, maintains neuronal, glial and downstream target signaling, and is significant as a regenerative therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 95-101 |
| Number of pages | 7 |
| Journal | Nanomedicine: Nanotechnology, Biology, and Medicine |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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Keywords
- Cavernous nerve injury (prostatectomy)
- Erectile dysfunction
- Peptide amphiphile nanofiber hydrogel
- Regeneration
- Sonic hedgehog
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Bioengineering
- Biomedical Engineering
- Molecular Medicine
- Materials Science(all)
- Pharmaceutical Science
Cite this
Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction. / Choe, Shawn; Bond, Christopher W.; Harrington, Daniel A.; Stupp, Samuel I; McVary, Kevin T.; Podlasek, Carol A.
In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 13, No. 1, 01.01.2017, p. 95-101.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction
AU - Choe, Shawn
AU - Bond, Christopher W.
AU - Harrington, Daniel A.
AU - Stupp, Samuel I
AU - McVary, Kevin T.
AU - Podlasek, Carol A.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Erectile dysfunction (ED) has high impact on quality of life in prostatectomy, diabetic and aging patients. An underlying mechanism is cavernous nerve (CN) injury, which causes ED in up to 80% of prostatectomy patients. We examine how sonic hedgehog (SHH) treatment with innovative peptide amphiphile nanofiber hydrogels (PA), promotes CN regeneration after injury. SHH and its receptors patched (PTCH1) and smoothened (SMO) are localized in PG neurons and glia. SMO undergoes anterograde transport to signal to downstream targets. With crush injury, PG neurons degenerate and undergo apoptosis. SHH protein decreases, SMO localization changes to the neuronal cell surface, and anterograde transport stops. With SHH treatment SHH is taken up at the injury site and undergoes retrograde transport to PG neurons, allowing SMO transport to occur, and neurons remain intact. SHH treatment prevents neuronal degeneration, maintains neuronal, glial and downstream target signaling, and is significant as a regenerative therapy.
AB - Erectile dysfunction (ED) has high impact on quality of life in prostatectomy, diabetic and aging patients. An underlying mechanism is cavernous nerve (CN) injury, which causes ED in up to 80% of prostatectomy patients. We examine how sonic hedgehog (SHH) treatment with innovative peptide amphiphile nanofiber hydrogels (PA), promotes CN regeneration after injury. SHH and its receptors patched (PTCH1) and smoothened (SMO) are localized in PG neurons and glia. SMO undergoes anterograde transport to signal to downstream targets. With crush injury, PG neurons degenerate and undergo apoptosis. SHH protein decreases, SMO localization changes to the neuronal cell surface, and anterograde transport stops. With SHH treatment SHH is taken up at the injury site and undergoes retrograde transport to PG neurons, allowing SMO transport to occur, and neurons remain intact. SHH treatment prevents neuronal degeneration, maintains neuronal, glial and downstream target signaling, and is significant as a regenerative therapy.
KW - Cavernous nerve injury (prostatectomy)
KW - Erectile dysfunction
KW - Peptide amphiphile nanofiber hydrogel
KW - Regeneration
KW - Sonic hedgehog
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UR - http://www.scopus.com/inward/citedby.url?scp=84995872936&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2016.08.032
DO - 10.1016/j.nano.2016.08.032
M3 - Article
VL - 13
SP - 95
EP - 101
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
SN - 1549-9634
IS - 1
ER -