Peptide-amphiphile nanofibers

A versatile scaffold for the preparation of self-assembling materials

Jeffrey D. Hartgerink, Elia Beniash, Samuel I Stupp

Research output: Contribution to journalArticle

917 Citations (Scopus)

Abstract

Twelve derivatives of peptide-amphiphile molecules, designed to self-assemble into nanofibers, are described. The scope of amino acid selection and alkyl tail modification in the peptide-amphiphile molecules are investigated, yielding nanofibers varying in morphology, surface chemistry, and potential bioactivity. The results demonstrate the chemically versatile nature of this supramolecular system and its high potential for manufacturing nanomaterials. In addition, three different modes of self-assembly resulting in nanofibers are described, including pH control, divalent ion induction, and concentration.

Original languageEnglish
Pages (from-to)5133-5138
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number8
DOIs
Publication statusPublished - Apr 16 2002

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Nanofibers
Peptides
Nanostructures
Ions
Amino Acids

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Peptide-amphiphile nanofibers : A versatile scaffold for the preparation of self-assembling materials. / Hartgerink, Jeffrey D.; Beniash, Elia; Stupp, Samuel I.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 8, 16.04.2002, p. 5133-5138.

Research output: Contribution to journalArticle

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