Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery

Miranda M. So, Neel A. Mansukhani, Erica B. Peters, Mazen S. Albaghdadi, Zheng Wang, Charles M. Rubert Pérez, Melina R. Kibbe, Samuel I Stupp

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Coassembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein-mimetic peptide, localize at plaque sites in low density lipoprotein receptor knockout (LDLR KO) mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, nontargeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein-mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis.

Original languageEnglish
Article number1700123
JournalAdvanced Biosystems
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 1 2018

Fingerprint

Nanofibers
Amphiphiles
Nanostructures
Atherosclerotic Plaques
Drug delivery
Peptides
Apolipoproteins
Pharmaceutical Preparations
Lipoproteins
LDL Receptors
Macrophages
Fluorescence microscopy
Cholesterol
Fluorescence Microscopy
Knockout Mice
Liver
Atherosclerosis
Molecules

Keywords

  • atherosclerosis
  • peptides
  • self-assembly
  • supramolecular chemistry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biomaterials
  • Biomedical Engineering

Cite this

So, M. M., Mansukhani, N. A., Peters, E. B., Albaghdadi, M. S., Wang, Z., Rubert Pérez, C. M., ... Stupp, S. I. (2018). Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery. Advanced Biosystems, 2(3), [1700123]. https://doi.org/10.1002/adbi.201700123

Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery. / So, Miranda M.; Mansukhani, Neel A.; Peters, Erica B.; Albaghdadi, Mazen S.; Wang, Zheng; Rubert Pérez, Charles M.; Kibbe, Melina R.; Stupp, Samuel I.

In: Advanced Biosystems, Vol. 2, No. 3, 1700123, 01.03.2018.

Research output: Contribution to journalArticle

So, MM, Mansukhani, NA, Peters, EB, Albaghdadi, MS, Wang, Z, Rubert Pérez, CM, Kibbe, MR & Stupp, SI 2018, 'Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery', Advanced Biosystems, vol. 2, no. 3, 1700123. https://doi.org/10.1002/adbi.201700123
So MM, Mansukhani NA, Peters EB, Albaghdadi MS, Wang Z, Rubert Pérez CM et al. Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery. Advanced Biosystems. 2018 Mar 1;2(3). 1700123. https://doi.org/10.1002/adbi.201700123
So, Miranda M. ; Mansukhani, Neel A. ; Peters, Erica B. ; Albaghdadi, Mazen S. ; Wang, Zheng ; Rubert Pérez, Charles M. ; Kibbe, Melina R. ; Stupp, Samuel I. / Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery. In: Advanced Biosystems. 2018 ; Vol. 2, No. 3.
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