Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery

Miranda M. So, Neel A. Mansukhani, Erica B. Peters, Mazen S. Albaghdadi, Zheng Wang, Charles M. Rubert Pérez, Melina R. Kibbe, Samuel I. Stupp

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8 Citations (Scopus)

Abstract

Coassembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein-mimetic peptide, localize at plaque sites in low density lipoprotein receptor knockout (LDLR KO) mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, nontargeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein-mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis.

Original languageEnglish
Article number1700123
JournalAdvanced Biosystems
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 2018

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Keywords

  • atherosclerosis
  • peptides
  • self-assembly
  • supramolecular chemistry

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

So, M. M., Mansukhani, N. A., Peters, E. B., Albaghdadi, M. S., Wang, Z., Rubert Pérez, C. M., Kibbe, M. R., & Stupp, S. I. (2018). Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery. Advanced Biosystems, 2(3), [1700123]. https://doi.org/10.1002/adbi.201700123