Peptide self-assembly for crafting functional biological materials

John B. Matson, R. Helen Zha, Samuel I. Stupp

Research output: Contribution to journalReview article

179 Citations (Scopus)

Abstract

Self-assembling, peptide-based scaffolds are frontrunners in the search for biomaterials with widespread impact in regenerative medicine. The inherent biocompatibility and cell signaling capabilities of peptides, in combination with control of secondary structure, has led to the development of a broad range of functional materials with potential for many novel therapies. More recently, membranes formed through complexation of peptide nanostructures with natural biopolymers have led to the development of hierarchically-structured constructs with potentially far-reaching applications in biology and medicine. In this review, we highlight recent advances in peptide-based gels and membranes, including work from our group and others. Specifically, we discuss the application of peptide-based materials in the regeneration of bone and enamel, cartilage, and the central nervous system, as well as the transplantation of islets, wound-healing, cardiovascular therapies, and treatment of erectile dysfunction after prostatectomy.

Original languageEnglish
Pages (from-to)225-235
Number of pages11
JournalCurrent Opinion in Solid State and Materials Science
Volume15
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Angiogenesis
  • Bioactive materials
  • Bioactive membranes
  • Bone regeneration
  • Cartilage regeneration
  • Enamel regeneration
  • Islet transplantation
  • Peptide amphiphiles
  • Regenerative medicine
  • Self-assembly

ASJC Scopus subject areas

  • Materials Science(all)

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