Photoinduced electron transfer for pyrenesulfonamide conjugates of tryptophan-containing peptides. Mitigation of fluoroprobe behavior in N-terminal labeling experiments

Guilford Jones, Lily N. Lu, Valentine Vullev, David J. Gosztola, Scott R. Greenfield, M. R. Wasielewski

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The (nitro)pyrenesulfonamide group has been attached to the N-terminus of tryptophan and tryptophan-containing peptides. Intramolecular electron transfer between pyrene and Trp indole side chains, observed by fluorescence quenching and laser flash photolysis, depends on the spacing between Pyr and Trp moieties and the strength of the electron acceptor.

Original languageEnglish
Pages (from-to)2385-2390
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number20
DOIs
Publication statusPublished - Oct 19 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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