Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser

K. T. Tsen, Shaw Wei D Tsen, Q. Fu, S. M. Lindsay, K. Kibler, B. Jacobs, T. C. Wu, Zhe Li, Hao Yan, Stephanie Cope, Sara Vaiana, Juliann G. Kiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We report a photonic approach for selective inactivation of viruses with a near-infrared ultrashort pulsed (USP) laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as M13 bacteriophage, tobacco mosaic virus (TMV) to pathogenic viruses like human papillomavirus (HPV) and human immunodeficiency virus (HIV). At the same time sensitive materials like human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7561
DOIs
Publication statusPublished - 2010
EventOptical Biopsy VII - San Francisco, CA, United States
Duration: Jan 25 2010Jan 28 2010

Other

OtherOptical Biopsy VII
CountryUnited States
CitySan Francisco, CA
Period1/25/101/28/10

Fingerprint

ultrashort pulsed lasers
Optics and Photonics
Virus Inactivation
viruses
Pulsed lasers
Viruses
Papillomaviridae
deactivation
Photonics
Lasers
photonics
Bacteriophage M13
Infrared radiation
Tobacco Mosaic Virus
Jurkat Cells
Disinfection
Virus Diseases
Blood
Virion
Dendritic Cells

Keywords

  • Femtosecond lasers
  • Inactivation of viruses
  • Photonics

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Tsen, K. T., Tsen, S. W. D., Fu, Q., Lindsay, S. M., Kibler, K., Jacobs, B., ... Kiang, J. G. (2010). Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7561). [75610W] https://doi.org/10.1117/12.841316

Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser. / Tsen, K. T.; Tsen, Shaw Wei D; Fu, Q.; Lindsay, S. M.; Kibler, K.; Jacobs, B.; Wu, T. C.; Li, Zhe; Yan, Hao; Cope, Stephanie; Vaiana, Sara; Kiang, Juliann G.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7561 2010. 75610W.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tsen, KT, Tsen, SWD, Fu, Q, Lindsay, SM, Kibler, K, Jacobs, B, Wu, TC, Li, Z, Yan, H, Cope, S, Vaiana, S & Kiang, JG 2010, Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7561, 75610W, Optical Biopsy VII, San Francisco, CA, United States, 1/25/10. https://doi.org/10.1117/12.841316
Tsen KT, Tsen SWD, Fu Q, Lindsay SM, Kibler K, Jacobs B et al. Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7561. 2010. 75610W https://doi.org/10.1117/12.841316
Tsen, K. T. ; Tsen, Shaw Wei D ; Fu, Q. ; Lindsay, S. M. ; Kibler, K. ; Jacobs, B. ; Wu, T. C. ; Li, Zhe ; Yan, Hao ; Cope, Stephanie ; Vaiana, Sara ; Kiang, Juliann G. / Photonic approach to the selective inactivation of viruses with a near-infrared ultrashort pulsed laser. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7561 2010.
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