Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury

Xiang Wang, Tian Xia, Matthew C. Duch, Zhaoxia Ji, Haiyuan Zhang, Ruibin Li, Bingbing Sun, Sijie Lin, Huan Meng, Yu Pei Liao, Meiying Wang, Tze Bin Song, Yang Yang, Mark C. Hersam, André E. Nel

Research output: Contribution to journalArticlepeer-review

126 Citations (Scopus)

Abstract

We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.

Original languageEnglish
Pages (from-to)3050-3061
Number of pages12
JournalNano letters
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 13 2012

Keywords

  • Multiwalled carbon nanotubes (MWCNTs)
  • biocompatible
  • dispersion
  • lung fibrosis
  • pluronic copolymer

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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