Porous NiTi for bone implants: A review

A. Bansiddhi, T. D. Sargeant, Samuel I Stupp, D. C. Dunand

Research output: Contribution to journalArticle

311 Citations (Scopus)

Abstract

NiTi foams are unique among biocompatible porous metals because of their high recovery strain (due to the shape-memory or superelastic effects) and their low stiffness facilitating integration with bone structures. To optimize NiTi foams for bone implant applications, two key areas are under active study: synthesis of foams with optimal architectures, microstructure and mechanical properties; and tailoring of biological interactions through modifications of pore surfaces. This article reviews recent research on NiTi foams for bone replacement, focusing on three specific topics: (i) surface modifications designed to create bio-inert porous NiTi surfaces with low Ni release and corrosion, as well as bioactive surfaces to enhance and accelerate biological activity; (ii) in vitro and in vivo biocompatibility studies to confirm the long-term safety of porous NiTi implants; and (iii) biological evaluations for specific applications, such as in intervertebral fusion devices and bone tissue scaffolds. Possible future directions for bio-performance and processing studies are discussed that could lead to optimized porous NiTi implants.

Original languageEnglish
Pages (from-to)773-782
Number of pages10
JournalActa Biomaterialia
Volume4
Issue number4
DOIs
Publication statusPublished - Jul 2008

Fingerprint

Foams
Bone
Bone and Bones
Tissue Scaffolds
Corrosion
Bioactivity
Shape memory effect
Biocompatibility
Surface treatment
Fusion reactions
Metals
Stiffness
Safety
Recovery
Equipment and Supplies
Mechanical properties
Microstructure
Processing
Research

Keywords

  • Bioactive surfaces
  • Biocompatibility
  • Cellular metals
  • Chemical modification
  • Nitinol

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology

Cite this

Porous NiTi for bone implants : A review. / Bansiddhi, A.; Sargeant, T. D.; Stupp, Samuel I; Dunand, D. C.

In: Acta Biomaterialia, Vol. 4, No. 4, 07.2008, p. 773-782.

Research output: Contribution to journalArticle

Bansiddhi, A, Sargeant, TD, Stupp, SI & Dunand, DC 2008, 'Porous NiTi for bone implants: A review', Acta Biomaterialia, vol. 4, no. 4, pp. 773-782. https://doi.org/10.1016/j.actbio.2008.02.009
Bansiddhi, A. ; Sargeant, T. D. ; Stupp, Samuel I ; Dunand, D. C. / Porous NiTi for bone implants : A review. In: Acta Biomaterialia. 2008 ; Vol. 4, No. 4. pp. 773-782.
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