Abstract
Submicronic and micronic particles of a promising biodegradable polymer, poly(desamino tyrosyl-tyrosine ethyl ester carbonate) [poly(DTE carbonate)], were produced by precipitation with compressed carbon dioxide as antisolvent. The effects of temperature, pressure, as well as initial concentration and flow rate of polymer solution on the particle size, size distribution, and morphology were investigated on a lab-scale apparatus with a coaxial injection nozzle. Among these operating parameters, pressure and temperature were found to have only mild effect on the product. Instead, the degree of agglomeration of the products can be manipulated with adjusting the operating parameters. The relationship between the operating variables and the sizes of primary particles reveals that the nature of this polymer is the dominant factor on its solid-state engineering in the course of its precipitation.
| Original language | English |
|---|---|
| Pages (from-to) | 211-216 |
| Number of pages | 6 |
| Journal | Journal of Supercritical Fluids |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Sep 2008 |
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Keywords
- Biodegradable polymer
- Poly(DTE carbonate)
- Precipitation with compressed antisolvent
- Supercritical fluid
- Tissue engineering
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Materials Science (miscellaneous)
- Physics and Astronomy (miscellaneous)
Cite this
Precipitation of a biodegradable polymer using compressed carbon dioxide as antisolvent. / Wu, Ke; Li, Jing.
In: Journal of Supercritical Fluids, Vol. 46, No. 2, 09.2008, p. 211-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Precipitation of a biodegradable polymer using compressed carbon dioxide as antisolvent
AU - Wu, Ke
AU - Li, Jing
PY - 2008/9
Y1 - 2008/9
N2 - Submicronic and micronic particles of a promising biodegradable polymer, poly(desamino tyrosyl-tyrosine ethyl ester carbonate) [poly(DTE carbonate)], were produced by precipitation with compressed carbon dioxide as antisolvent. The effects of temperature, pressure, as well as initial concentration and flow rate of polymer solution on the particle size, size distribution, and morphology were investigated on a lab-scale apparatus with a coaxial injection nozzle. Among these operating parameters, pressure and temperature were found to have only mild effect on the product. Instead, the degree of agglomeration of the products can be manipulated with adjusting the operating parameters. The relationship between the operating variables and the sizes of primary particles reveals that the nature of this polymer is the dominant factor on its solid-state engineering in the course of its precipitation.
AB - Submicronic and micronic particles of a promising biodegradable polymer, poly(desamino tyrosyl-tyrosine ethyl ester carbonate) [poly(DTE carbonate)], were produced by precipitation with compressed carbon dioxide as antisolvent. The effects of temperature, pressure, as well as initial concentration and flow rate of polymer solution on the particle size, size distribution, and morphology were investigated on a lab-scale apparatus with a coaxial injection nozzle. Among these operating parameters, pressure and temperature were found to have only mild effect on the product. Instead, the degree of agglomeration of the products can be manipulated with adjusting the operating parameters. The relationship between the operating variables and the sizes of primary particles reveals that the nature of this polymer is the dominant factor on its solid-state engineering in the course of its precipitation.
KW - Biodegradable polymer
KW - Poly(DTE carbonate)
KW - Precipitation with compressed antisolvent
KW - Supercritical fluid
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=47949086872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47949086872&partnerID=8YFLogxK
U2 - 10.1016/j.supflu.2008.02.007
DO - 10.1016/j.supflu.2008.02.007
M3 - Article
VL - 46
SP - 211
EP - 216
JO - Journal of Supercritical Fluids
JF - Journal of Supercritical Fluids
SN - 0896-8446
IS - 2
ER -