Precipitation of a biodegradable polymer using compressed carbon dioxide as antisolvent

Ke Wu, Jing Li

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Submicronic and micronic particles of a promising biodegradable polymer, poly(desamino tyrosyl-tyrosine ethyl ester carbonate) [poly(DTE carbonate)], were produced by precipitation with compressed carbon dioxide as antisolvent. The effects of temperature, pressure, as well as initial concentration and flow rate of polymer solution on the particle size, size distribution, and morphology were investigated on a lab-scale apparatus with a coaxial injection nozzle. Among these operating parameters, pressure and temperature were found to have only mild effect on the product. Instead, the degree of agglomeration of the products can be manipulated with adjusting the operating parameters. The relationship between the operating variables and the sizes of primary particles reveals that the nature of this polymer is the dominant factor on its solid-state engineering in the course of its precipitation.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalJournal of Supercritical Fluids
Volume46
Issue number2
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Biodegradable polymers
Carbon Dioxide
carbon dioxide
Carbon dioxide
Carbonates
polymers
Polymer solutions
Nozzles
Esters
Polymers
Agglomeration
tyrosine
Particle size
Flow rate
products
agglomeration
Temperature
nozzles
esters
carbonates

Keywords

  • Biodegradable polymer
  • Poly(DTE carbonate)
  • Precipitation with compressed antisolvent
  • Supercritical fluid
  • Tissue engineering

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Science (miscellaneous)
  • Physics and Astronomy (miscellaneous)

Cite this

Precipitation of a biodegradable polymer using compressed carbon dioxide as antisolvent. / Wu, Ke; Li, Jing.

In: Journal of Supercritical Fluids, Vol. 46, No. 2, 09.2008, p. 211-216.

Research output: Contribution to journalArticle

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