Proton-Coupled Electron Transfer Drives Long-Range Proton Translocation in Bioinspired Systems

Emmanuel Odella, Brian L. Wadsworth, S. Jimena Mora, Joshua J. Goings, Mioy T. Huynh, Devens Gust, Thomas A. Moore, Gary F. Moore, Sharon Hammes-Schiffer, Ana L. Moore

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Abstract

Proton-coupled electron transfer (PCET) combines the movement of fundamental charged species to form an essential link between electron- and proton-transport reactions in bioenergetics and catalysis in general. The length scale over which proton transport may occur within PCET processes and the thermodynamic consequences of the resulting proton chemical potential to the oxidation reaction driving these PCET processes have not been generally established. Here we report the design of bioinspired molecules that employ oxidation-reduction processes to move reversibly two, three, and four protons via a Grotthuss-type mechanism along hydrogen-bonded networks up to ∼16 Å in length. These molecules are composed of benzimidazole moieties linking a phenol to the final proton acceptor, a cyclohexylimine. Following electrochemical oxidation of the phenol, the appearance of an infrared band at 1660 cm-1 signals proton arrival at the terminal basic site. Switching the electrode potential to reducing conditions reverses the proton translocation and resets the structure to the initial species. In addition to mimicking the first step of the iconic PCET process used by the Tyrz-His190 redox relay in photosystem II to oxidize water, this work specifically addresses theoretically and experimentally the length scale over which PCET processes may occur. The thermodynamic findings from these redox-driven, bioinspired "proton wires" have implications for understanding and rationally designing pumps for the generation of proton-motive force in artificial and reengineered photosynthesis, as well as for management of proton activity around catalytic sites, including those for water oxidation and oxygen reduction.

Original languageEnglish
Pages (from-to)14057-14061
Number of pages5
JournalJournal of the American Chemical Society
Volume141
Issue number36
DOIs
Publication statusPublished - Sep 11 2019

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Odella, E., Wadsworth, B. L., Mora, S. J., Goings, J. J., Huynh, M. T., Gust, D., Moore, T. A., Moore, G. F., Hammes-Schiffer, S., & Moore, A. L. (2019). Proton-Coupled Electron Transfer Drives Long-Range Proton Translocation in Bioinspired Systems. Journal of the American Chemical Society, 141(36), 14057-14061. https://doi.org/10.1021/jacs.9b06978