Quantum Dot Molecules Assembled with Genetically Engineered Proteins

Shi You Ding, Marcus Jones, Melvin P. Tucker, Jovan M. Nedeljkovic, Joseph Wall, Martha N. Simon, Gary Rumbles, Michael E. Himmel

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

We report the assembly of quantum dots using an approach that attempts to capitalize on the self-assembling properties of naturally occurring proteins. Colloidal quantum dots made of cadmium selenide core and a zinc sulfide shell, (CdSe)ZnS, were incubated with a genetically modified, bacterial cellulosomal protein, cohesin, and the resultant mixture subjected to fractionation using high-pressure size exclusion chromatography (HPSEC). We note that the HPSEC profile is distinctly bimodal. The peak corresponding to particles of larger effective hydrodynamic radius (Re) contains a plethora of sizable protein-coated, quantum dot assemblies with a predominance of structures that are trefoil-shaped. The fraction corresponding to particles of smaller R e contains individual, protein-coated quantum dots that are chemically different from their larger counterparts. This overall procedure is shown to successfully assemble novel quantum dot bioconjugates that exhibit light harvesting properties as well as providing an effective method of purifying quantum dot samples.

Original languageEnglish
Pages (from-to)1581-1585
Number of pages5
JournalNano Letters
Volume3
Issue number11
DOIs
Publication statusPublished - Nov 2003

Fingerprint

Semiconductor quantum dots
quantum dots
proteins
Proteins
Molecules
molecules
Size exclusion chromatography
chromatography
exclusion
cadmium selenides
Zinc sulfide
zinc sulfides
Bacterial Proteins
Fractionation
assembling
fractionation
Cadmium
assemblies
Hydrodynamics
assembly

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Ding, S. Y., Jones, M., Tucker, M. P., Nedeljkovic, J. M., Wall, J., Simon, M. N., ... Himmel, M. E. (2003). Quantum Dot Molecules Assembled with Genetically Engineered Proteins. Nano Letters, 3(11), 1581-1585. https://doi.org/10.1021/nl034578t

Quantum Dot Molecules Assembled with Genetically Engineered Proteins. / Ding, Shi You; Jones, Marcus; Tucker, Melvin P.; Nedeljkovic, Jovan M.; Wall, Joseph; Simon, Martha N.; Rumbles, Gary; Himmel, Michael E.

In: Nano Letters, Vol. 3, No. 11, 11.2003, p. 1581-1585.

Research output: Contribution to journalArticle

Ding, SY, Jones, M, Tucker, MP, Nedeljkovic, JM, Wall, J, Simon, MN, Rumbles, G & Himmel, ME 2003, 'Quantum Dot Molecules Assembled with Genetically Engineered Proteins', Nano Letters, vol. 3, no. 11, pp. 1581-1585. https://doi.org/10.1021/nl034578t
Ding SY, Jones M, Tucker MP, Nedeljkovic JM, Wall J, Simon MN et al. Quantum Dot Molecules Assembled with Genetically Engineered Proteins. Nano Letters. 2003 Nov;3(11):1581-1585. https://doi.org/10.1021/nl034578t
Ding, Shi You ; Jones, Marcus ; Tucker, Melvin P. ; Nedeljkovic, Jovan M. ; Wall, Joseph ; Simon, Martha N. ; Rumbles, Gary ; Himmel, Michael E. / Quantum Dot Molecules Assembled with Genetically Engineered Proteins. In: Nano Letters. 2003 ; Vol. 3, No. 11. pp. 1581-1585.
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