Quantum image scanning microscopy

Concept and considerations towards applicability

Ron Tenne, Uri Rossman, Batel Rephael, Yonatan Israel, Alexander Krupinski-Ptaszek, Radek Lapkiewicz, Yaron Silberberg, Dan Oron

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Technological advancements in the creation, manipulation and detection of quantum states of light have motivated the application of such states to overcome classical limits in sensing and imaging. In particular, there has been a surge of recent interest in super-resolution imaging based on principles of quantum optics. However, the application of such schemes for practical imaging of biological samples is demanding in terms of signal-to-noise ratio, speed of acquisition and robustness with respect to sample labeling. Here, we re-introduce the concept of quantum image scanning microscopy (Q-ISM), a super-resolution method that enhances the classical image scanning microscopy (ISM) method by measuring photon correlations. Q-ISM was already utilized to achieve super-resolved images of a biological sample labeled with fluorescent nanoscrystals whose contrast is based entirely on a quantum optical phenomenon, photon antibunching. We present here an experimental demonstration of the method and discuss with further details its prospects for application in life science microscopy.

Original languageEnglish
Title of host publicationOptical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology
EditorsSelim M. Shahriar, Jacob Scheuer
PublisherSPIE
ISBN (Electronic)9781510625105
DOIs
Publication statusPublished - Jan 1 2019
EventOptical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology 2019 - San Francisco, United States
Duration: Feb 2 2019Feb 7 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10934
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceOptical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology 2019
CountryUnited States
CitySan Francisco
Period2/2/192/7/19

Fingerprint

Microscopy
Scanning
Microscopic examination
microscopy
scanning
Super-resolution
Imaging
Imaging techniques
Photon
Photons
Quantum optics
Quantum Optics
life sciences
quantum optics
Classical Limit
Life sciences
Surge
Optical resolving power
photons
Quantum State

Keywords

  • Image scanning microscopy
  • Photon antibunching
  • Quantum imaging
  • Super-resolution microscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Tenne, R., Rossman, U., Rephael, B., Israel, Y., Krupinski-Ptaszek, A., Lapkiewicz, R., ... Oron, D. (2019). Quantum image scanning microscopy: Concept and considerations towards applicability. In S. M. Shahriar, & J. Scheuer (Eds.), Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology [109341P] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10934). SPIE. https://doi.org/10.1117/12.2514459

Quantum image scanning microscopy : Concept and considerations towards applicability. / Tenne, Ron; Rossman, Uri; Rephael, Batel; Israel, Yonatan; Krupinski-Ptaszek, Alexander; Lapkiewicz, Radek; Silberberg, Yaron; Oron, Dan.

Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology. ed. / Selim M. Shahriar; Jacob Scheuer. SPIE, 2019. 109341P (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10934).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tenne, R, Rossman, U, Rephael, B, Israel, Y, Krupinski-Ptaszek, A, Lapkiewicz, R, Silberberg, Y & Oron, D 2019, Quantum image scanning microscopy: Concept and considerations towards applicability. in SM Shahriar & J Scheuer (eds), Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology., 109341P, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10934, SPIE, Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology 2019, San Francisco, United States, 2/2/19. https://doi.org/10.1117/12.2514459
Tenne R, Rossman U, Rephael B, Israel Y, Krupinski-Ptaszek A, Lapkiewicz R et al. Quantum image scanning microscopy: Concept and considerations towards applicability. In Shahriar SM, Scheuer J, editors, Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology. SPIE. 2019. 109341P. (Proceedings of SPIE - The International Society for Optical Engineering). https://doi.org/10.1117/12.2514459
Tenne, Ron ; Rossman, Uri ; Rephael, Batel ; Israel, Yonatan ; Krupinski-Ptaszek, Alexander ; Lapkiewicz, Radek ; Silberberg, Yaron ; Oron, Dan. / Quantum image scanning microscopy : Concept and considerations towards applicability. Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology. editor / Selim M. Shahriar ; Jacob Scheuer. SPIE, 2019. (Proceedings of SPIE - The International Society for Optical Engineering).
@inproceedings{d0fcb2fa998148b9b16464b6c1ebdb7e,
title = "Quantum image scanning microscopy: Concept and considerations towards applicability",
abstract = "Technological advancements in the creation, manipulation and detection of quantum states of light have motivated the application of such states to overcome classical limits in sensing and imaging. In particular, there has been a surge of recent interest in super-resolution imaging based on principles of quantum optics. However, the application of such schemes for practical imaging of biological samples is demanding in terms of signal-to-noise ratio, speed of acquisition and robustness with respect to sample labeling. Here, we re-introduce the concept of quantum image scanning microscopy (Q-ISM), a super-resolution method that enhances the classical image scanning microscopy (ISM) method by measuring photon correlations. Q-ISM was already utilized to achieve super-resolved images of a biological sample labeled with fluorescent nanoscrystals whose contrast is based entirely on a quantum optical phenomenon, photon antibunching. We present here an experimental demonstration of the method and discuss with further details its prospects for application in life science microscopy.",
keywords = "Image scanning microscopy, Photon antibunching, Quantum imaging, Super-resolution microscopy",
author = "Ron Tenne and Uri Rossman and Batel Rephael and Yonatan Israel and Alexander Krupinski-Ptaszek and Radek Lapkiewicz and Yaron Silberberg and Dan Oron",
year = "2019",
month = "1",
day = "1",
doi = "10.1117/12.2514459",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Shahriar, {Selim M.} and Jacob Scheuer",
booktitle = "Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology",

}

TY - GEN

T1 - Quantum image scanning microscopy

T2 - Concept and considerations towards applicability

AU - Tenne, Ron

AU - Rossman, Uri

AU - Rephael, Batel

AU - Israel, Yonatan

AU - Krupinski-Ptaszek, Alexander

AU - Lapkiewicz, Radek

AU - Silberberg, Yaron

AU - Oron, Dan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Technological advancements in the creation, manipulation and detection of quantum states of light have motivated the application of such states to overcome classical limits in sensing and imaging. In particular, there has been a surge of recent interest in super-resolution imaging based on principles of quantum optics. However, the application of such schemes for practical imaging of biological samples is demanding in terms of signal-to-noise ratio, speed of acquisition and robustness with respect to sample labeling. Here, we re-introduce the concept of quantum image scanning microscopy (Q-ISM), a super-resolution method that enhances the classical image scanning microscopy (ISM) method by measuring photon correlations. Q-ISM was already utilized to achieve super-resolved images of a biological sample labeled with fluorescent nanoscrystals whose contrast is based entirely on a quantum optical phenomenon, photon antibunching. We present here an experimental demonstration of the method and discuss with further details its prospects for application in life science microscopy.

AB - Technological advancements in the creation, manipulation and detection of quantum states of light have motivated the application of such states to overcome classical limits in sensing and imaging. In particular, there has been a surge of recent interest in super-resolution imaging based on principles of quantum optics. However, the application of such schemes for practical imaging of biological samples is demanding in terms of signal-to-noise ratio, speed of acquisition and robustness with respect to sample labeling. Here, we re-introduce the concept of quantum image scanning microscopy (Q-ISM), a super-resolution method that enhances the classical image scanning microscopy (ISM) method by measuring photon correlations. Q-ISM was already utilized to achieve super-resolved images of a biological sample labeled with fluorescent nanoscrystals whose contrast is based entirely on a quantum optical phenomenon, photon antibunching. We present here an experimental demonstration of the method and discuss with further details its prospects for application in life science microscopy.

KW - Image scanning microscopy

KW - Photon antibunching

KW - Quantum imaging

KW - Super-resolution microscopy

UR - http://www.scopus.com/inward/record.url?scp=85064866175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064866175&partnerID=8YFLogxK

U2 - 10.1117/12.2514459

DO - 10.1117/12.2514459

M3 - Conference contribution

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology

A2 - Shahriar, Selim M.

A2 - Scheuer, Jacob

PB - SPIE

ER -