Radical-Enriched Artificial Melanin

Wei Cao, Alex J. Mantanona, Haochuan Mao, Naneki C. McCallum, Yang Jiao, Claudia Battistella, Valeria Caponetti, Nanzhi Zang, Matthew P. Thompson, Marco Montalti, J. Fraser Stoddart, Michael R. Wasielewski, Jeffrey D. Rinehart, Nathan C. Gianneschi

Research output: Contribution to journalArticle

Abstract

Melanin is a class of ubiquitous, heterogeneous, polymeric pigments. One of the most unusual features of melanin is the presence of stable persistent radicals, which has been reported to relate to ionizing radiation protection, including X-rays and gamma rays. In this work, we aimed to increase the radical content by introducing nitroxide radicals into synthetic melanin nanomaterials. Nanoparticles (NPs) were prepared by copolymerization of a stable radical modified monomer with the monomer dopamine. The radical content increased to 1 order of magnitude higher than that of the conventional melanin-like material, polydopamine. These radical NPs can enter human epidermal keratinocytes and form perinuclear caps, mimicking natural melanin synthesized by melanocytes. We demonstrated that these NPs display protective properties by scavenging reactive oxygen species, one of the most important biological effects of ionizing radiation exposure. This finding may have potential application for materials capable of mitigating side effects of clinical radiation therapy.

Original languageEnglish
Pages (from-to)5759-5767
Number of pages9
JournalChemistry of Materials
Volume32
Issue number13
DOIs
Publication statusPublished - Jul 14 2020

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

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  • Cite this

    Cao, W., Mantanona, A. J., Mao, H., McCallum, N. C., Jiao, Y., Battistella, C., Caponetti, V., Zang, N., Thompson, M. P., Montalti, M., Stoddart, J. F., Wasielewski, M. R., Rinehart, J. D., & Gianneschi, N. C. (2020). Radical-Enriched Artificial Melanin. Chemistry of Materials, 32(13), 5759-5767. https://doi.org/10.1021/acs.chemmater.0c01573