Rapid, Mild, and Selective Ketone and Aldehyde Hydroboration/Reduction Mediated by a Simple Lanthanide Catalyst

Victoria L. Weidner, Christopher J. Barger, Massimiliano Delferro, Tracy L. Lohr, Tobin J Marks

Research output: Contribution to journalArticle

61 Citations (Scopus)


Rapid, clean hydroboration of ketones and aldehydes with HBpin is achieved using the homoleptic rare-earth catalyst La[N(SiMe3)2]3 (LaNTMS). The reaction employs low catalyst loadings (0.01-1 mol % LaNTMS), proceeds rapidly (>99% in 5 min) at 25 °C, and is moderately air-tolerant. Additionally, this hydroboration has good functional group compatibility, including halides, nitro groups, and nitriles, and is exclusively carbonyl-selective in the presence of alkenes and alkynes.

Original languageEnglish
Pages (from-to)1244-1247
Number of pages4
JournalACS Catalysis
Issue number2
Publication statusPublished - Feb 3 2017



  • carbonyl hydroboration
  • chemoselective hydroboration
  • homogeneous catalysis
  • ketone/aldehyde reduction
  • lanthanide

ASJC Scopus subject areas

  • Catalysis

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