Real-Time Multicolor DNA Detection with Chemoresponsive Diffraction Gratings and Nanoparticle Probes

Ryan C. Bailey, Jwa Min Nam, Chad A. Mirkin, Joseph T Hupp

Research output: Contribution to journalArticle

131 Citations (Scopus)


We report a real-time DNA detection method that utilizes single-strand DNA-modified nanoparticle probes and micropatterned chemoresponsive diffraction gratings interrogated simultaneously at multiple laser wavelengths. The surface-bound nanoparticle probe based assay with the chemoresponsive diffraction grating signal transduction scheme results in an experimentally simple DNA detection protocol, displaying attributes of both detection methodologies: the high sensitivity and selectivity afforded by nanoparticle probes and the experimental simplicity, wavelength-dependent resonant enhancement features, and miniaturization potential provided by the diffraction-based sensing technology.

Original languageEnglish
Pages (from-to)13541-13547
Number of pages7
JournalJournal of the American Chemical Society
Issue number44
Publication statusPublished - Nov 5 2003


ASJC Scopus subject areas

  • Chemistry(all)

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