Reversible self-assembly of superstructured networks

Ronit Freeman, Ming Han, Zaida Álvarez, Jacob A. Lewis, James R. Wester, Nicholas Stephanopoulos, Mark T. McClendon, Cheyenne Lynsky, Jacqueline M. Godbe, Hussain Sangji, Erik Luijten, Samuel I Stupp

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Soft structures in nature such as protein assemblies can organize reversibly into functional and often hierarchical architectures through noncovalent interactions. Molecularly encoding this dynamic capability in synthetic materials has remained an elusive goal. We report on hydrogels of peptide-DNA conjugates and peptides that organize into superstructures of intertwined filaments that disassemble upon the addition of molecules or changes in charge density. Experiments and simulations demonstrate that this response requires large scale spatial redistribution of molecules directed by strong noncovalent interactions among them. Simulations also suggest that the chemically reversible structures can only occur within a limited range of supramolecular cohesive energies. Storage moduli of the hydrogels change reversibly as superstructures form and disappear, as does the phenotype of neural cells in contact with these materials.

Original languageEnglish
JournalScience
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Hydrogels
Self assembly
Peptides
Molecules
Charge density
Elastic moduli
DNA
Proteins
Experiments

ASJC Scopus subject areas

  • General

Cite this

Freeman, R., Han, M., Álvarez, Z., Lewis, J. A., Wester, J. R., Stephanopoulos, N., ... Stupp, S. I. (Accepted/In press). Reversible self-assembly of superstructured networks. Science. https://doi.org/10.1126/science.aat6141

Reversible self-assembly of superstructured networks. / Freeman, Ronit; Han, Ming; Álvarez, Zaida; Lewis, Jacob A.; Wester, James R.; Stephanopoulos, Nicholas; McClendon, Mark T.; Lynsky, Cheyenne; Godbe, Jacqueline M.; Sangji, Hussain; Luijten, Erik; Stupp, Samuel I.

In: Science, 01.01.2018.

Research output: Contribution to journalArticle

Freeman, R, Han, M, Álvarez, Z, Lewis, JA, Wester, JR, Stephanopoulos, N, McClendon, MT, Lynsky, C, Godbe, JM, Sangji, H, Luijten, E & Stupp, SI 2018, 'Reversible self-assembly of superstructured networks', Science. https://doi.org/10.1126/science.aat6141
Freeman R, Han M, Álvarez Z, Lewis JA, Wester JR, Stephanopoulos N et al. Reversible self-assembly of superstructured networks. Science. 2018 Jan 1. https://doi.org/10.1126/science.aat6141
Freeman, Ronit ; Han, Ming ; Álvarez, Zaida ; Lewis, Jacob A. ; Wester, James R. ; Stephanopoulos, Nicholas ; McClendon, Mark T. ; Lynsky, Cheyenne ; Godbe, Jacqueline M. ; Sangji, Hussain ; Luijten, Erik ; Stupp, Samuel I. / Reversible self-assembly of superstructured networks. In: Science. 2018.
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