Abstract
Soft structures in nature such as protein assemblies can organize reversibly into functional and often hierarchical architectures through noncovalent interactions. Molecularly encoding this dynamic capability in synthetic materials has remained an elusive goal. We report on hydrogels of peptide-DNA conjugates and peptides that organize into superstructures of intertwined filaments that disassemble upon the addition of molecules or changes in charge density. Experiments and simulations demonstrate that this response requires large scale spatial redistribution of molecules directed by strong noncovalent interactions among them. Simulations also suggest that the chemically reversible structures can only occur within a limited range of supramolecular cohesive energies. Storage moduli of the hydrogels change reversibly as superstructures form and disappear, as does the phenotype of neural cells in contact with these materials.
| Original language | English |
|---|---|
| Journal | Science |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2018 |
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ASJC Scopus subject areas
- General
Cite this
Reversible self-assembly of superstructured networks. / Freeman, Ronit; Han, Ming; Álvarez, Zaida; Lewis, Jacob A.; Wester, James R.; Stephanopoulos, Nicholas; McClendon, Mark T.; Lynsky, Cheyenne; Godbe, Jacqueline M.; Sangji, Hussain; Luijten, Erik; Stupp, Samuel I.
In: Science, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reversible self-assembly of superstructured networks
AU - Freeman, Ronit
AU - Han, Ming
AU - Álvarez, Zaida
AU - Lewis, Jacob A.
AU - Wester, James R.
AU - Stephanopoulos, Nicholas
AU - McClendon, Mark T.
AU - Lynsky, Cheyenne
AU - Godbe, Jacqueline M.
AU - Sangji, Hussain
AU - Luijten, Erik
AU - Stupp, Samuel I
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Soft structures in nature such as protein assemblies can organize reversibly into functional and often hierarchical architectures through noncovalent interactions. Molecularly encoding this dynamic capability in synthetic materials has remained an elusive goal. We report on hydrogels of peptide-DNA conjugates and peptides that organize into superstructures of intertwined filaments that disassemble upon the addition of molecules or changes in charge density. Experiments and simulations demonstrate that this response requires large scale spatial redistribution of molecules directed by strong noncovalent interactions among them. Simulations also suggest that the chemically reversible structures can only occur within a limited range of supramolecular cohesive energies. Storage moduli of the hydrogels change reversibly as superstructures form and disappear, as does the phenotype of neural cells in contact with these materials.
AB - Soft structures in nature such as protein assemblies can organize reversibly into functional and often hierarchical architectures through noncovalent interactions. Molecularly encoding this dynamic capability in synthetic materials has remained an elusive goal. We report on hydrogels of peptide-DNA conjugates and peptides that organize into superstructures of intertwined filaments that disassemble upon the addition of molecules or changes in charge density. Experiments and simulations demonstrate that this response requires large scale spatial redistribution of molecules directed by strong noncovalent interactions among them. Simulations also suggest that the chemically reversible structures can only occur within a limited range of supramolecular cohesive energies. Storage moduli of the hydrogels change reversibly as superstructures form and disappear, as does the phenotype of neural cells in contact with these materials.
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UR - http://www.scopus.com/inward/citedby.url?scp=85055291282&partnerID=8YFLogxK
U2 - 10.1126/science.aat6141
DO - 10.1126/science.aat6141
M3 - Article
C2 - 30287619
AN - SCOPUS:85055291282
JO - Science
JF - Science
SN - 0036-8075
ER -