Rewiring of cyanobacterial metabolism for hydrogen production: Synthetic biology approaches and challenges

Anagha Krishnan, Xiao Qian, Gennady Ananyev, Desmond S. Lun, G Charles Dismukes

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

With the demand for renewable energy growing, hydrogen (H2) is becoming an attractive energy carrier. Developing H2 production technologies with near-net zero carbon emissions is a major challenge for the “H2 economy.” Certain cyanobacteria inherently possess enzymes, nitrogenases, and bidirectional hydrogenases that are capable of H2 evolution using sunlight, making them ideal cell factories for photocatalytic conversion of water to H2. With the advances in synthetic biology, cyanobacteria are currently being developed as a “plug and play” chassis to produce H2. This chapter describes the metabolic pathways involved and the theoretical limits to cyanobacterial H2 production and summarizes the metabolic engineering technologies pursued.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages171-213
Number of pages43
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1080
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Synthetic Biology
Cyanobacteria
Hydrogen production
Metabolism
Hydrogen
Renewable Energy
Metabolic engineering
Technology
Metabolic Engineering
Hydrogenase
Nitrogenase
Sunlight
Engineering technology
Chassis
Metabolic Networks and Pathways
Industrial plants
Carbon
Water
Enzymes

Keywords

  • Bioenergy
  • Biofuel
  • BioH
  • Cyanobacteria
  • Dark fermentation
  • Hight-throughput screen
  • Hydrogenase
  • Metabolic engineering
  • Metabolism
  • Nitrogenase
  • Photobiological H
  • Synthetic biology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Krishnan, A., Qian, X., Ananyev, G., Lun, D. S., & Dismukes, G. C. (2018). Rewiring of cyanobacterial metabolism for hydrogen production: Synthetic biology approaches and challenges. In Advances in Experimental Medicine and Biology (pp. 171-213). (Advances in Experimental Medicine and Biology; Vol. 1080). Springer New York LLC. https://doi.org/10.1007/978-981-13-0854-3_8

Rewiring of cyanobacterial metabolism for hydrogen production : Synthetic biology approaches and challenges. / Krishnan, Anagha; Qian, Xiao; Ananyev, Gennady; Lun, Desmond S.; Dismukes, G Charles.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 171-213 (Advances in Experimental Medicine and Biology; Vol. 1080).

Research output: Chapter in Book/Report/Conference proceedingChapter

Krishnan, A, Qian, X, Ananyev, G, Lun, DS & Dismukes, GC 2018, Rewiring of cyanobacterial metabolism for hydrogen production: Synthetic biology approaches and challenges. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1080, Springer New York LLC, pp. 171-213. https://doi.org/10.1007/978-981-13-0854-3_8
Krishnan A, Qian X, Ananyev G, Lun DS, Dismukes GC. Rewiring of cyanobacterial metabolism for hydrogen production: Synthetic biology approaches and challenges. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 171-213. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-13-0854-3_8
Krishnan, Anagha ; Qian, Xiao ; Ananyev, Gennady ; Lun, Desmond S. ; Dismukes, G Charles. / Rewiring of cyanobacterial metabolism for hydrogen production : Synthetic biology approaches and challenges. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 171-213 (Advances in Experimental Medicine and Biology).
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