Role of the subunit interactions in the conformational transitions in adult human hemoglobin: An explicit solvent molecular dynamics study

Olaniyi K. Yusuff, Jonathan O. Babalola, Giovanni Bussi, Simone Raugei

Research output: Contribution to journalArticle

13 Citations (Scopus)


Hemoglobin exhibits allosteric structural changes upon ligand binding due to the dynamic interactions between the ligand binding sites, the amino acids residues and some other solutes present under physiological conditions. In the present study, the dynamical and quaternary structural changes occurring in two unligated (deoxy-) T structures and two fully ligated (oxy-) R, R2 structures of adult human hemoglobin were investigated with molecular dynamics. It is shown that, in the submicrosecond time scale, there is no marked difference in the global dynamics of the amino acid residues in both the oxy- and the deoxy-forms of the individual structures. In addition, the R, R2 are relatively stable and do not present quaternary conformational changes within the time scale of our simulations, while the T structure is dynamically more flexible and exhibited the T → R quaternary conformational transition, which is propagated by the relative rotation of the residues at the α1β2 and α2β1 interface.

Original languageEnglish
Pages (from-to)11004-11009
Number of pages6
JournalJournal of Physical Chemistry B
Issue number36
Publication statusPublished - Sep 13 2012


ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this