Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000

Timothy C. Wang, Nicolaas A. Vermeulen, In S oo Kim, Alex B F Martinson, J. Fraser Stoddart, Joseph T Hupp, Omar K. Farha

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The synthesis of NU-1000, a highly robust mesoporous (containing pores >2 nm) metal-organic framework (MOF), can be conducted efficiently on a multigram scale from inexpensive starting materials. Tetrabromopyrene and (4-(ethoxycarbonyl)phenyl)boronic acid can easily be coupled to prepare the requisite organic strut with four metal-binding sites in the form of four carboxylic acids, while zirconyl chloride octahydrate is used as a precursor for the well-defined metal oxide clusters. NU-1000 has been reported as an excellent candidate for the separation of gases, and it is a versatile scaffold for heterogeneous catalysis. In particular, it is ideal for the catalytic deactivation of nerve agents, and it shows great promise as a new generic platform for a wide range of applications. Multiple post-synthetic modification protocols have been developed using NU-1000 as the parent material, making it a potentially useful scaffold for several catalytic applications. The procedure for the preparation of NU-1000 can be scaled up reliably, and it is suitable for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg-2.5 g of NU-1000. The entire synthesis is performed without purification by column chromatography and can be completed within 10 d.

Original languageEnglish
Pages (from-to)149-162
Number of pages14
JournalNature Protocols
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Metals
Scaffolds
Boronic Acids
Column chromatography
Struts
Carboxylic Acids
Catalysis
Oxides
Purification
Chromatography
Chlorides
Gases
Binding Sites
Acids
Nerve Agents

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wang, T. C., Vermeulen, N. A., Kim, I. S. O., Martinson, A. B. F., Stoddart, J. F., Hupp, J. T., & Farha, O. K. (2016). Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000. Nature Protocols, 11(1), 149-162. https://doi.org/10.1038/nprot.2016.001

Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000. / Wang, Timothy C.; Vermeulen, Nicolaas A.; Kim, In S oo; Martinson, Alex B F; Stoddart, J. Fraser; Hupp, Joseph T; Farha, Omar K.

In: Nature Protocols, Vol. 11, No. 1, 01.01.2016, p. 149-162.

Research output: Contribution to journalArticle

Wang, TC, Vermeulen, NA, Kim, ISO, Martinson, ABF, Stoddart, JF, Hupp, JT & Farha, OK 2016, 'Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000', Nature Protocols, vol. 11, no. 1, pp. 149-162. https://doi.org/10.1038/nprot.2016.001
Wang, Timothy C. ; Vermeulen, Nicolaas A. ; Kim, In S oo ; Martinson, Alex B F ; Stoddart, J. Fraser ; Hupp, Joseph T ; Farha, Omar K. / Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000. In: Nature Protocols. 2016 ; Vol. 11, No. 1. pp. 149-162.
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