Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex

Arup Mukherjee, Dipankar Srimani, Subrata Chakraborty, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.

Original languageEnglish
Pages (from-to)8888-8891
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number28
DOIs
Publication statusPublished - Jul 22 2015

Fingerprint

Nitriles
Hydrogenation
Cobalt
Amines
Organic Chemistry
Precious metals
Metals
Atoms
Catalysts

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex. / Mukherjee, Arup; Srimani, Dipankar; Chakraborty, Subrata; Ben-David, Yehoshoa; Milstein, David.

In: Journal of the American Chemical Society, Vol. 137, No. 28, 22.07.2015, p. 8888-8891.

Research output: Contribution to journalArticle

Mukherjee, Arup ; Srimani, Dipankar ; Chakraborty, Subrata ; Ben-David, Yehoshoa ; Milstein, David. / Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex. In: Journal of the American Chemical Society. 2015 ; Vol. 137, No. 28. pp. 8888-8891.
@article{b570425e59db4988bc4d199876ae6432,
title = "Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex",
abstract = "The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.",
author = "Arup Mukherjee and Dipankar Srimani and Subrata Chakraborty and Yehoshoa Ben-David and David Milstein",
year = "2015",
month = "7",
day = "22",
doi = "10.1021/jacs.5b04879",
language = "English",
volume = "137",
pages = "8888--8891",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "28",

}

TY - JOUR

T1 - Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex

AU - Mukherjee, Arup

AU - Srimani, Dipankar

AU - Chakraborty, Subrata

AU - Ben-David, Yehoshoa

AU - Milstein, David

PY - 2015/7/22

Y1 - 2015/7/22

N2 - The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.

AB - The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.

UR - http://www.scopus.com/inward/record.url?scp=84937713149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937713149&partnerID=8YFLogxK

U2 - 10.1021/jacs.5b04879

DO - 10.1021/jacs.5b04879

M3 - Article

VL - 137

SP - 8888

EP - 8891

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 28

ER -