Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex

Arup Mukherjee, Dipankar Srimani, Subrata Chakraborty, Yehoshoa Ben-David, David Milstein

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139 Citations (Scopus)

Abstract

The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.

Original languageEnglish
Pages (from-to)8888-8891
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number28
DOIs
Publication statusPublished - Jul 22 2015

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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