Selective Hydrogenation of Nitriles to Secondary Imines Catalyzed by an Iron Pincer Complex

Subrata Chakraborty; David Milstein

doi:10.1021/acscatal.7b00906

Selective Hydrogenation of Nitriles to Secondary Imines Catalyzed by an Iron Pincer Complex

Subrata Chakraborty, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Selective hydrogenation of nitriles to secondary imines catalyzed by an iron complex, the pincer complex (iPr-PNP)Fe(H)Br(CO), in the presence of catalytic base, is reported. A wide range of (hetero)aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines under mild conditions.

Original language	English
Pages (from-to)	3968-3972
Number of pages	5
Journal	ACS Catalysis
Volume	7
Issue number	6
DOIs	https://doi.org/10.1021/acscatal.7b00906
Publication status	Published - Jun 2 2017

Keywords

hydrogenation
iron
nitriles
pincer
secondary imines

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1021/acscatal.7b00906

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title = "Selective Hydrogenation of Nitriles to Secondary Imines Catalyzed by an Iron Pincer Complex",

abstract = "Selective hydrogenation of nitriles to secondary imines catalyzed by an iron complex, the pincer complex (iPr-PNP)Fe(H)Br(CO), in the presence of catalytic base, is reported. A wide range of (hetero)aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines under mild conditions.",

keywords = "hydrogenation, iron, nitriles, pincer, secondary imines",

author = "Subrata Chakraborty and David Milstein",

note = "Funding Information: This research was supported by the European Research Council (ERC AdG 692775) and by the Kimmel Center for Molecular Design. D.M. holds the Israel Matz Professorial Chair of Organic Chemistry. S.C. thanks the Swiss Friends of the Weizmann Institute of Science for a generous postdoctoral fellowship.",

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T1 - Selective Hydrogenation of Nitriles to Secondary Imines Catalyzed by an Iron Pincer Complex

AU - Chakraborty, Subrata

AU - Milstein, David

N1 - Funding Information: This research was supported by the European Research Council (ERC AdG 692775) and by the Kimmel Center for Molecular Design. D.M. holds the Israel Matz Professorial Chair of Organic Chemistry. S.C. thanks the Swiss Friends of the Weizmann Institute of Science for a generous postdoctoral fellowship.

PY - 2017/6/2

Y1 - 2017/6/2

N2 - Selective hydrogenation of nitriles to secondary imines catalyzed by an iron complex, the pincer complex (iPr-PNP)Fe(H)Br(CO), in the presence of catalytic base, is reported. A wide range of (hetero)aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines under mild conditions.

AB - Selective hydrogenation of nitriles to secondary imines catalyzed by an iron complex, the pincer complex (iPr-PNP)Fe(H)Br(CO), in the presence of catalytic base, is reported. A wide range of (hetero)aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines under mild conditions.

KW - hydrogenation

KW - iron

KW - nitriles

KW - pincer

KW - secondary imines

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JF - ACS Catalysis

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Selective Hydrogenation of Nitriles to Secondary Imines Catalyzed by an Iron Pincer Complex

Abstract

Keywords

ASJC Scopus subject areas

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