Selective N-Formylation of Amines with H2 and CO2 Catalyzed by Cobalt Pincer Complexes

Prosenjit Daw; Subrata Chakraborty; Gregory Leitus; Yael Diskin-Posner; Yehoshoa Ben-David; David Milstein

doi:10.1021/acscatal.7b00116

Selective N-Formylation of Amines with H₂ and CO₂ Catalyzed by Cobalt Pincer Complexes

Prosenjit Daw, Subrata Chakraborty, Gregory Leitus, Yael Diskin-Posner, Yehoshoa Ben-David, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

N-formylation of amines utilizing CO₂ in the presence of reducing agents constitute an important methodology in organic synthesis. Presented herein is a selective N-formylation of amines with CO₂ and H₂ catalyzed by complexes of Earth-abundant cobalt. A wide range of amines were converted to their corresponding formamides under CO₂ and H₂ pressure, catalyzed by Co-PNP pincer complex, generating water as the sole byproduct.

Original language	English
Pages (from-to)	2500-2504
Number of pages	5
Journal	ACS Catalysis
Volume	7
Issue number	4
DOIs	https://doi.org/10.1021/acscatal.7b00116
Publication status	Published - Apr 7 2017

Keywords

CO
cobalt
formylation
hydrogenation
pincer

ASJC Scopus subject areas

Catalysis

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10.1021/acscatal.7b00116

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AU - Daw, Prosenjit

AU - Chakraborty, Subrata

AU - Leitus, Gregory

AU - Diskin-Posner, Yael

AU - Ben-David, Yehoshoa

AU - Milstein, David

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N2 - N-formylation of amines utilizing CO2 in the presence of reducing agents constitute an important methodology in organic synthesis. Presented herein is a selective N-formylation of amines with CO2 and H2 catalyzed by complexes of Earth-abundant cobalt. A wide range of amines were converted to their corresponding formamides under CO2 and H2 pressure, catalyzed by Co-PNP pincer complex, generating water as the sole byproduct.

AB - N-formylation of amines utilizing CO2 in the presence of reducing agents constitute an important methodology in organic synthesis. Presented herein is a selective N-formylation of amines with CO2 and H2 catalyzed by complexes of Earth-abundant cobalt. A wide range of amines were converted to their corresponding formamides under CO2 and H2 pressure, catalyzed by Co-PNP pincer complex, generating water as the sole byproduct.

KW - CO

KW - cobalt

KW - formylation

KW - hydrogenation

KW - pincer

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