Selective N-Formylation of Amines with H2 and CO2 Catalyzed by Cobalt Pincer Complexes

Prosenjit Daw, Subrata Chakraborty, Gregory Leitus, Yael Diskin-Posner, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)


N-formylation of amines utilizing CO2 in the presence of reducing agents constitute an important methodology in organic synthesis. Presented herein is a selective N-formylation of amines with CO2 and H2 catalyzed by complexes of Earth-abundant cobalt. A wide range of amines were converted to their corresponding formamides under CO2 and H2 pressure, catalyzed by Co-PNP pincer complex, generating water as the sole byproduct.

Original languageEnglish
Pages (from-to)2500-2504
Number of pages5
JournalACS Catalysis
Issue number4
Publication statusPublished - Apr 7 2017


  • CO
  • cobalt
  • formylation
  • hydrogenation
  • pincer

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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