Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents

Steve R. Bull, Mustafa O. Guler, Rafael E. Bras, Thomas J. Meade, Samuel I. Stupp

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Self-assembled peptide amphiphile nanofibers have been investigated for their potential use as in vivo scaffolds for tissue engineering and drug delivery applications. We report here the synthesis of magnetic resonance (MR) active peptide amphiphile molecules that self-assemble into spherical and fiber-like nanostructures, enhancing T 1, relaxation time. This new class of MR contrast agents can potentially be used to combine high-resolution three-dimensional MR fate mapping of tissue-engineered scaffolds with targeting of specific cellular receptors.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalNano letters
Volume5
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents'. Together they form a unique fingerprint.

  • Cite this