Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents

Steve R. Bull, Mustafa O. Guler, Rafael E. Bras, Thomas J. Meade, Samuel I Stupp

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

Self-assembled peptide amphiphile nanofibers have been investigated for their potential use as in vivo scaffolds for tissue engineering and drug delivery applications. We report here the synthesis of magnetic resonance (MR) active peptide amphiphile molecules that self-assemble into spherical and fiber-like nanostructures, enhancing T 1, relaxation time. This new class of MR contrast agents can potentially be used to combine high-resolution three-dimensional MR fate mapping of tissue-engineered scaffolds with targeting of specific cellular receptors.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalNano Letters
Volume5
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Amphiphiles
Magnetic resonance
Nanofibers
Magnetic resonance imaging
Contrast Media
Peptides
peptides
magnetic resonance
Tissue Scaffolds
tissue engineering
Bioelectric potentials
Scaffolds (biology)
Drug delivery
Tissue engineering
Relaxation time
Nanostructures
delivery
drugs
relaxation time
Molecules

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents. / Bull, Steve R.; Guler, Mustafa O.; Bras, Rafael E.; Meade, Thomas J.; Stupp, Samuel I.

In: Nano Letters, Vol. 5, No. 1, 01.2005, p. 1-4.

Research output: Contribution to journalArticle

Bull, Steve R. ; Guler, Mustafa O. ; Bras, Rafael E. ; Meade, Thomas J. ; Stupp, Samuel I. / Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents. In: Nano Letters. 2005 ; Vol. 5, No. 1. pp. 1-4.
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