Self-assembled signaling aptamer DNA arrays for protein detection

Chenxiang Lin, Evaldas Katilius, Yan Liu, Hao Yan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we report a DNA tile directed self-assembly of signaling aptamers into high-density nanoarrays for highly sensitive detection of protein molecules. The high local density of the signaling aptamers displayed on the self-assembled DNA arrays allowed us to detect sub-nanomolar concentrations of protein bound to the aptamers using confocal fluorescence microscope imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.

Original languageEnglish
Title of host publication3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006
Pages161-162
Number of pages2
Publication statusPublished - 2006
Event3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 - Snowbird, UT, United States
Duration: Apr 23 2006Apr 27 2006

Other

Other3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006
CountryUnited States
CitySnowbird, UT
Period4/23/064/27/06

Fingerprint

DNA
Proteins
Sensor arrays
Microarrays
Tile
Self assembly
Microscopes
Fluorescence
Imaging techniques
Molecules
Water

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Cite this

Lin, C., Katilius, E., Liu, Y., & Yan, H. (2006). Self-assembled signaling aptamer DNA arrays for protein detection. In 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 (pp. 161-162)

Self-assembled signaling aptamer DNA arrays for protein detection. / Lin, Chenxiang; Katilius, Evaldas; Liu, Yan; Yan, Hao.

3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006. 2006. p. 161-162.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lin, C, Katilius, E, Liu, Y & Yan, H 2006, Self-assembled signaling aptamer DNA arrays for protein detection. in 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006. pp. 161-162, 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006, Snowbird, UT, United States, 4/23/06.
Lin C, Katilius E, Liu Y, Yan H. Self-assembled signaling aptamer DNA arrays for protein detection. In 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006. 2006. p. 161-162
Lin, Chenxiang ; Katilius, Evaldas ; Liu, Yan ; Yan, Hao. / Self-assembled signaling aptamer DNA arrays for protein detection. 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006. 2006. pp. 161-162
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