Self-assembled signaling aptamer DNA arrays for protein detection

Chenxiang Lin, Evaldas Katilius, Yan Liu, Hao Yan

Research output: Contribution to conferencePaper

Abstract

Here we report a DNA tile directed self-assembly of signaling aptamers into high-density nanoarrays for highly sensitive detection of protein molecules. The high local density of the signaling aptamers displayed on the self-assembled DNA arrays allowed us to detect sub-nanomolar concentrations of protein bound to the aptamers using confocal fluorescence microscope imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.

Original languageEnglish
Pages161-162
Number of pages2
Publication statusPublished - Dec 1 2006
Event3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 - Snowbird, UT, United States
Duration: Apr 23 2006Apr 27 2006

Other

Other3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006
CountryUnited States
CitySnowbird, UT
Period4/23/064/27/06

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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  • Cite this

    Lin, C., Katilius, E., Liu, Y., & Yan, H. (2006). Self-assembled signaling aptamer DNA arrays for protein detection. 161-162. Paper presented at 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006, Snowbird, UT, United States.