Self-assembling biomaterials

L-lysine-dendron-substituted cholesteryl-(L-lactic acid)

Harm Anton Klok, Julia J. Hwang, Jeffrey D. Hartgerink, Samuel I Stupp

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

This report describes the synthesis and supramolecular organization of a novel class of linear-dendritic block copolymers. The molecules, which are termed rodcoil dendrons, consist of a cholesterol moiety that is attached to L-lysine dendrons of three different generations via a biodegradable oligo(L-lactic acid) spacer. Whereas the molecules exhibit very poor ordering in the dry state, different supramolecular morphologies were observed in the hydrated state. Cholesteryl-(L-lactic acid)23̄-(L-lysine)G1 and cholesteryl-(L-lactic acid)23̄-(L-lysine)G2 self-assemble into lamellar structures with periodicities that depend on degree of hydration. At low degrees of hydration, lamellar ordering was also observed for cholesteryl-(L-lactic acid)22̄-(L-lysine)G3. However, at 50 wt%, water steric hindrance in the highly hydrated L-lysine dendrons no longer allows lamellar ordering, and discrete nanosized aggregates are formed. Evidence for the formation of such nanoaggregates was obtained from dynamic light scattering, electron microscopy, and atomic force microscopy. These rodcoil dendron biomaterials could be of potential interest as temporary molecular scaffolds for cell and tissue engineering.

Original languageEnglish
Pages (from-to)6101-6111
Number of pages11
JournalMacromolecules
Volume35
Issue number16
DOIs
Publication statusPublished - Jul 30 2002

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Biocompatible Materials
Lactic acid
Biomaterials
Lysine
Lactic Acid
Dendrimers
Hydration
Cell engineering
Molecules
Lamellar structures
Cholesterol
Bioelectric potentials
Dynamic light scattering
Scaffolds (biology)
Tissue engineering
Electron microscopy
Block copolymers
Atomic force microscopy
dendron
Water

ASJC Scopus subject areas

  • Materials Chemistry

Cite this

Self-assembling biomaterials : L-lysine-dendron-substituted cholesteryl-(L-lactic acid). / Klok, Harm Anton; Hwang, Julia J.; Hartgerink, Jeffrey D.; Stupp, Samuel I.

In: Macromolecules, Vol. 35, No. 16, 30.07.2002, p. 6101-6111.

Research output: Contribution to journalArticle

Klok, Harm Anton ; Hwang, Julia J. ; Hartgerink, Jeffrey D. ; Stupp, Samuel I. / Self-assembling biomaterials : L-lysine-dendron-substituted cholesteryl-(L-lactic acid). In: Macromolecules. 2002 ; Vol. 35, No. 16. pp. 6101-6111.
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