Self-assembly and mineralization of peptide-amphiphile nanofibers

J. D. Hartgerink, E. Beniash, S. I. Stupp

Research output: Contribution to journalArticle

2869 Citations (Scopus)

Abstract

We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone.

Original languageEnglish
Pages (from-to)1684-1688
Number of pages5
JournalScience
Volume294
Issue number5547
DOIs
Publication statusPublished - Nov 23 2001

ASJC Scopus subject areas

  • General

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