Abstract
Programming self-assembled designer DNA crystals with various lattices and functions is one of the most important goals for nanofabrication using nucleic acids. The resulting porous materials possess atomic precision for several potential applications that rely on crystalline lattices and cavities. Herein, we present a rationally designed and self-assembled 3D DNA crystal lattice with hexagonal symmetry. In our design, two 21-base oligonucleotides are used to form a duplex motif that further assembles into a 3D array. The interactions between the strands are programmed using Watson–Crick base-pairing. The six-fold symmetry, as well as the chirality, is directed by the Holliday junctions formed between the duplex motifs. The rationally designed DNA crystal provides a new avenue that could create self-assembled macromolecular 3D crystalline lattices with atomic precision. In addition, the structure contains a highly organized array of well-defined cavities that are suitable for future applications with immobilized guests.
| Original language | English |
|---|---|
| Pages (from-to) | 12504-12507 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 57 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - Sep 17 2018 |
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Keywords
- crystallography
- DNA nanotechnology
- porous materials
- self-assembled crystals
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
Cite this
Self-Assembly of a 3D DNA Crystal Structure with Rationally Designed Six-Fold Symmetry. / Zhang, Fei; Simmons, Chad R.; Gates, Jade; Liu, Yan; Yan, Hao.
In: Angewandte Chemie - International Edition, Vol. 57, No. 38, 17.09.2018, p. 12504-12507.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Self-Assembly of a 3D DNA Crystal Structure with Rationally Designed Six-Fold Symmetry
AU - Zhang, Fei
AU - Simmons, Chad R.
AU - Gates, Jade
AU - Liu, Yan
AU - Yan, Hao
PY - 2018/9/17
Y1 - 2018/9/17
N2 - Programming self-assembled designer DNA crystals with various lattices and functions is one of the most important goals for nanofabrication using nucleic acids. The resulting porous materials possess atomic precision for several potential applications that rely on crystalline lattices and cavities. Herein, we present a rationally designed and self-assembled 3D DNA crystal lattice with hexagonal symmetry. In our design, two 21-base oligonucleotides are used to form a duplex motif that further assembles into a 3D array. The interactions between the strands are programmed using Watson–Crick base-pairing. The six-fold symmetry, as well as the chirality, is directed by the Holliday junctions formed between the duplex motifs. The rationally designed DNA crystal provides a new avenue that could create self-assembled macromolecular 3D crystalline lattices with atomic precision. In addition, the structure contains a highly organized array of well-defined cavities that are suitable for future applications with immobilized guests.
AB - Programming self-assembled designer DNA crystals with various lattices and functions is one of the most important goals for nanofabrication using nucleic acids. The resulting porous materials possess atomic precision for several potential applications that rely on crystalline lattices and cavities. Herein, we present a rationally designed and self-assembled 3D DNA crystal lattice with hexagonal symmetry. In our design, two 21-base oligonucleotides are used to form a duplex motif that further assembles into a 3D array. The interactions between the strands are programmed using Watson–Crick base-pairing. The six-fold symmetry, as well as the chirality, is directed by the Holliday junctions formed between the duplex motifs. The rationally designed DNA crystal provides a new avenue that could create self-assembled macromolecular 3D crystalline lattices with atomic precision. In addition, the structure contains a highly organized array of well-defined cavities that are suitable for future applications with immobilized guests.
KW - crystallography
KW - DNA nanotechnology
KW - porous materials
KW - self-assembled crystals
UR - http://www.scopus.com/inward/record.url?scp=85052815979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052815979&partnerID=8YFLogxK
U2 - 10.1002/anie.201807223
DO - 10.1002/anie.201807223
M3 - Article
C2 - 30066355
AN - SCOPUS:85052815979
VL - 57
SP - 12504
EP - 12507
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 38
ER -