@article{f9c52b21772b43f3b18d9c449fb37a72,
title = "Self-Assembly of a 3D DNA Crystal Structure with Rationally Designed Six-Fold Symmetry",
abstract = "Programming self-assembled designer DNA crystals with various lattices and functions is one of the most important goals for nanofabrication using nucleic acids. The resulting porous materials possess atomic precision for several potential applications that rely on crystalline lattices and cavities. Herein, we present a rationally designed and self-assembled 3D DNA crystal lattice with hexagonal symmetry. In our design, two 21-base oligonucleotides are used to form a duplex motif that further assembles into a 3D array. The interactions between the strands are programmed using Watson–Crick base-pairing. The six-fold symmetry, as well as the chirality, is directed by the Holliday junctions formed between the duplex motifs. The rationally designed DNA crystal provides a new avenue that could create self-assembled macromolecular 3D crystalline lattices with atomic precision. In addition, the structure contains a highly organized array of well-defined cavities that are suitable for future applications with immobilized guests.",
keywords = "DNA nanotechnology, crystallography, porous materials, self-assembled crystals",
author = "Fei Zhang and Simmons, {Chad R.} and Jade Gates and Yan Liu and Hao Yan",
note = "Funding Information: The Berkeley Center for Structural Biology (BL 5.0.2) is supported in part by the Howard Hughes Medical Institute. The Advanced Light Source is a Department of Energy Office of Science User Facility under Contract No. DE‐AC02‐05CH11231. The AMX (17‐ID) beamline of The Life Science Biomedical Technology Research (LSBR) resource is primarily supported by the National Institute of Health, National Institute of General Medical Sciences (NIGMS) through a Biomedical Technology Research Resource P41 grant (P41GM111244), and by the DOE Office of Biological and Environmental Research (KP1605010). As a National Synchrotron Light Source II facility resource at Brookhaven National Laboratory, work performed at the LSBR is supported in part by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences Program under contract number and DE‐SC0012704 (KC0401040). We thank Dr. Marc Allaire from the BCSB beamline 5.0.2, and Drs. Alexei Soares and Jean Jakoncic at the LSBR beamline 17‐ID (AMX) for invaluable technical support. The Yan lab was supported by grants to H.Y. and Y.L. from the NSF (nos. 1360635 and 1334109), the ARO (no. W911NF‐12‐1‐0420), and the NIH (no. R01GM104960). H.Y. was also supported by the Presidential Strategic Initiative Fund from Arizona State University. Funding Information: The Berkeley Center for Structural Biology (BL 5.0.2) is supported in part by the Howard Hughes Medical Institute. The Advanced Light Source is a Department of Energy Office of Science User Facility under Contract No. DE-AC02-05CH11231. The AMX (17-ID) beamline of The Life Science Biomedical Technology Research (LSBR) resource is primarily supported by the National Institute of Health, National Institute of General Medical Sciences (NIGMS) through a Biomedical Technology Research Resource P41 grant (P41GM111244), and by the DOE Office of Biological and Environmental Research (KP1605010). As a National Synchrotron Light Source II facility resource at Brookhaven National Laboratory, work performed at the LSBR is supported in part by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences Program under contract number and DE-SC0012704 (KC0401040). We thank Dr. Marc Allaire from the BCSB beamline 5.0.2, and Drs. Alexei Soares and Jean Jakoncic at the LSBR beamline 17-ID (AMX) for invaluable technical support. The Yan lab was supported by grants to H.Y. and Y.L. from the NSF (nos. 1360635 and 1334109), the ARO (no. W911NF-12-1-0420), and the NIH (no. R01GM104960). H.Y. was also supported by the Presidential Strategic Initiative Fund from Arizona State University. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = sep,
day = "17",
doi = "10.1002/anie.201807223",
language = "English",
volume = "57",
pages = "12504--12507",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "38",
}