Self-assembly of DNA rings from scaffold-free DNA tiles

Yang Yang, Zhao Zhao, Fei Zhang, Jeanette Nangreave, Yan Liu, Hao Yan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report a scaffold-free approach in which four- and six-helix DNA bundle units, assembled from a small number of single stranded DNA oligonucleotides precisely arranged in networks of contiguous and semicrossover strands, are connected into DNA nano rings. Nearly uniform structures with well-defined diameters of 53 ± 7, 81 ± 9, 85 ± 8, and 166 ± 13 nm were achieved by introducing uniform, in-plane curvature to the repeating units. We demonstrate that precise higher order assemblies can be achieved by fine tuning the particular features of the individual building blocks.

Original languageEnglish
Pages (from-to)1862-1866
Number of pages5
JournalNano Letters
Volume13
Issue number4
DOIs
Publication statusPublished - Apr 10 2013

Fingerprint

tiles
Tile
Scaffolds
Self assembly
self assembly
DNA
deoxyribonucleic acid
helices
Single-Stranded DNA
rings
Oligonucleotides
oligonucleotides
Tuning
strands
assemblies
bundles
tuning
curvature

Keywords

  • DNA nanotechnology
  • DNA rings
  • DNA self-assembly
  • scaffold free

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering
  • Medicine(all)

Cite this

Self-assembly of DNA rings from scaffold-free DNA tiles. / Yang, Yang; Zhao, Zhao; Zhang, Fei; Nangreave, Jeanette; Liu, Yan; Yan, Hao.

In: Nano Letters, Vol. 13, No. 4, 10.04.2013, p. 1862-1866.

Research output: Contribution to journalArticle

Yang, Y, Zhao, Z, Zhang, F, Nangreave, J, Liu, Y & Yan, H 2013, 'Self-assembly of DNA rings from scaffold-free DNA tiles', Nano Letters, vol. 13, no. 4, pp. 1862-1866. https://doi.org/10.1021/nl400859d
Yang, Yang ; Zhao, Zhao ; Zhang, Fei ; Nangreave, Jeanette ; Liu, Yan ; Yan, Hao. / Self-assembly of DNA rings from scaffold-free DNA tiles. In: Nano Letters. 2013 ; Vol. 13, No. 4. pp. 1862-1866.
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