Self-assembly of giant peptide nanobelts

Honggang Cui, Takahiro Muraoka, Andrew G. Cheetham, Samuel I Stupp

Research output: Contribution to journalArticle

272 Citations (Scopus)

Abstract

Many alkylated peptide amphiphiles have been reported to self-assemble into cylindrical nanofibers with diameters on the order of a few nanometers and micrometer scale lengths; these nanostructures can be highly bioactive and are of great interest in many biomedical applications. We have discovered the sequences for these molecules that can eliminate all curvature from the nanostructures they form in water and generate completely flat nanobelts with giant dimensions relative to previously reported systems. The nanobelts have fairly monodisperse widths on the order of 150 nm and lengths of up to 0.1 mm. The sequences have an alternating sequence with hydrophobic and hydrophilic side chains and variations in monomer concentration generate a "broom" morphology with twisted ribbons that reveals the mechanism through which giant nanobelts form. Interestingly, a variation in pH generates reversibly periodic 2 nm grooves on the surfaces of the nanobelts. With proper functionalization, these nanostructures offer a novel architecture to present epitopes to cells for therapeutic applications.

Original languageEnglish
Pages (from-to)945-951
Number of pages7
JournalNano Letters
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 11 2009

Fingerprint

Nanobelts
Self assembly
Peptides
peptides
self assembly
Nanostructures
activity (biology)
grooves
ribbons
micrometers
monomers
curvature
Epitopes
Amphiphiles
Nanofibers
cells
water
molecules
Monomers
Molecules

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Self-assembly of giant peptide nanobelts. / Cui, Honggang; Muraoka, Takahiro; Cheetham, Andrew G.; Stupp, Samuel I.

In: Nano Letters, Vol. 9, No. 3, 11.03.2009, p. 945-951.

Research output: Contribution to journalArticle

Cui, H, Muraoka, T, Cheetham, AG & Stupp, SI 2009, 'Self-assembly of giant peptide nanobelts', Nano Letters, vol. 9, no. 3, pp. 945-951. https://doi.org/10.1021/nl802813f
Cui, Honggang ; Muraoka, Takahiro ; Cheetham, Andrew G. ; Stupp, Samuel I. / Self-assembly of giant peptide nanobelts. In: Nano Letters. 2009 ; Vol. 9, No. 3. pp. 945-951.
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