Self-assembly of highly ordered peptide amphiphile metalloporphyrin arrays

H. Christopher Fry, Jamie M. Garcia, Matthew J. Medina, Ulises M. Ricoy, David J. Gosztola, Maxim P. Nikiforov, Liam C. Palmer, Samuel I Stupp

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Long fibers assembled from peptide amphiphiles capable of binding the metalloporphyrin zinc protoporphyrin IX ((PPIX)Zn) have been synthesized. Rational peptide design was employed to generate a peptide, c16-AHL 3K3-CO2H, capable of forming a β-sheet structure that propagates into larger fibrous structures. A porphyrin-binding site, a single histidine, was engineered into the peptide sequence in order to bind (PPIX)Zn to provide photophysical functionality. The resulting system indicates control from the molecular level to the macromolecular level with a high order of porphyrin organization. UV/visible and circular dichroism spectroscopies were employed to detail molecular organization, whereas electron microscopy and atomic force microscopy aided in macromolecular characterization. Preliminary picosecond transient absorption data are also reported. Reduced hemin, (PPIX)FeII, was also employed to highlight the material's versatility and tunability.

Original languageEnglish
Pages (from-to)14646-14649
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number36
DOIs
Publication statusPublished - Sep 12 2012

Fingerprint

Metalloporphyrins
Amphiphiles
Self assembly
Peptides
Porphyrins
Circular dichroism spectroscopy
Hemin
Atomic Force Microscopy
Binding sites
Circular Dichroism
Histidine
Electron microscopy
Atomic force microscopy
Spectrum Analysis
Electron Microscopy
Zinc
Binding Sites
Control systems
Fibers

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Fry, H. C., Garcia, J. M., Medina, M. J., Ricoy, U. M., Gosztola, D. J., Nikiforov, M. P., ... Stupp, S. I. (2012). Self-assembly of highly ordered peptide amphiphile metalloporphyrin arrays. Journal of the American Chemical Society, 134(36), 14646-14649. https://doi.org/10.1021/ja304674d

Self-assembly of highly ordered peptide amphiphile metalloporphyrin arrays. / Fry, H. Christopher; Garcia, Jamie M.; Medina, Matthew J.; Ricoy, Ulises M.; Gosztola, David J.; Nikiforov, Maxim P.; Palmer, Liam C.; Stupp, Samuel I.

In: Journal of the American Chemical Society, Vol. 134, No. 36, 12.09.2012, p. 14646-14649.

Research output: Contribution to journalArticle

Fry, HC, Garcia, JM, Medina, MJ, Ricoy, UM, Gosztola, DJ, Nikiforov, MP, Palmer, LC & Stupp, SI 2012, 'Self-assembly of highly ordered peptide amphiphile metalloporphyrin arrays', Journal of the American Chemical Society, vol. 134, no. 36, pp. 14646-14649. https://doi.org/10.1021/ja304674d
Fry HC, Garcia JM, Medina MJ, Ricoy UM, Gosztola DJ, Nikiforov MP et al. Self-assembly of highly ordered peptide amphiphile metalloporphyrin arrays. Journal of the American Chemical Society. 2012 Sep 12;134(36):14646-14649. https://doi.org/10.1021/ja304674d
Fry, H. Christopher ; Garcia, Jamie M. ; Medina, Matthew J. ; Ricoy, Ulises M. ; Gosztola, David J. ; Nikiforov, Maxim P. ; Palmer, Liam C. ; Stupp, Samuel I. / Self-assembly of highly ordered peptide amphiphile metalloporphyrin arrays. In: Journal of the American Chemical Society. 2012 ; Vol. 134, No. 36. pp. 14646-14649.
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