SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

Victoria M. Szlag, Matthew J. Styles, Lindsey R. Madison, Antonio R. Campos, Bharat Wagh, Dustin Sprouse, George C Schatz, Theresa M. Reineke, Christy L. Haynes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.

Original languageEnglish
Pages (from-to)842-846
Number of pages5
JournalACS Sensors
Volume1
Issue number7
DOIs
Publication statusPublished - Jul 22 2016

Keywords

  • DFT modeling
  • film over nanospheres
  • glycopolymers
  • ricin
  • surface-enhanced raman spectroscopy

ASJC Scopus subject areas

  • Bioengineering
  • Fluid Flow and Transfer Processes
  • Process Chemistry and Technology
  • Instrumentation

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    Szlag, V. M., Styles, M. J., Madison, L. R., Campos, A. R., Wagh, B., Sprouse, D., Schatz, G. C., Reineke, T. M., & Haynes, C. L. (2016). SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers. ACS Sensors, 1(7), 842-846. https://doi.org/10.1021/acssensors.6b00209