SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

Victoria M. Szlag, Matthew J. Styles, Lindsey R. Madison, Antonio R. Campos, Bharat Wagh, Dustin Sprouse, George C Schatz, Theresa M. Reineke, Christy L. Haynes

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.

Original languageEnglish
Pages (from-to)842-846
Number of pages5
JournalACS Sensors
Volume1
Issue number7
DOIs
Publication statusPublished - Jul 22 2016

Fingerprint

Galactosamine
Ricin
Raman spectroscopy
Raman scattering
Liquids
Polymers
Water
food
Raman spectra
polymers
matrices
liquids
predictions
water
interactions

Keywords

  • DFT modeling
  • film over nanospheres
  • glycopolymers
  • ricin
  • surface-enhanced raman spectroscopy

ASJC Scopus subject areas

  • Bioengineering
  • Fluid Flow and Transfer Processes
  • Process Chemistry and Technology
  • Instrumentation

Cite this

Szlag, V. M., Styles, M. J., Madison, L. R., Campos, A. R., Wagh, B., Sprouse, D., ... Haynes, C. L. (2016). SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers. ACS Sensors, 1(7), 842-846. https://doi.org/10.1021/acssensors.6b00209

SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers. / Szlag, Victoria M.; Styles, Matthew J.; Madison, Lindsey R.; Campos, Antonio R.; Wagh, Bharat; Sprouse, Dustin; Schatz, George C; Reineke, Theresa M.; Haynes, Christy L.

In: ACS Sensors, Vol. 1, No. 7, 22.07.2016, p. 842-846.

Research output: Contribution to journalArticle

Szlag, VM, Styles, MJ, Madison, LR, Campos, AR, Wagh, B, Sprouse, D, Schatz, GC, Reineke, TM & Haynes, CL 2016, 'SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers', ACS Sensors, vol. 1, no. 7, pp. 842-846. https://doi.org/10.1021/acssensors.6b00209
Szlag VM, Styles MJ, Madison LR, Campos AR, Wagh B, Sprouse D et al. SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers. ACS Sensors. 2016 Jul 22;1(7):842-846. https://doi.org/10.1021/acssensors.6b00209
Szlag, Victoria M. ; Styles, Matthew J. ; Madison, Lindsey R. ; Campos, Antonio R. ; Wagh, Bharat ; Sprouse, Dustin ; Schatz, George C ; Reineke, Theresa M. ; Haynes, Christy L. / SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers. In: ACS Sensors. 2016 ; Vol. 1, No. 7. pp. 842-846.
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