Shape-Dependent Relaxivity of Nanoparticle-Based T1 Magnetic Resonance Imaging Contrast Agents

Kayla S B Culver, Yu Jin Shin, Matthew W. Rotz, Thomas J. Meade, Mark C Hersam, Teri W Odom

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Gold nanostars functionalized with Gd(III) have shown significant promise as contrast agents for magnetic resonance imaging (MRI) because of their anisotropic, branched shape. However, the size and shape polydispersity of as-synthesized gold nanostars have precluded efforts to develop a rigorous relationship between the gold nanostar structure (e.g., number of branches) and relaxivity of surface-bound Gd(III). This paper describes the use of a centrifugal separation method that can produce structurally refined populations of gold nanostars and is compatible with Gd(III) functionalization. Combined transmission electron microscopy and relaxivity analyses revealed that the increased number of nanostar branches was correlated with enhanced relaxivity. By identifying the underlying relaxivity mechanisms for Gd(III)-functionalized gold nanostars, we can inform the design of high-performance MRI contrast agents.

Original languageEnglish
Pages (from-to)22103-22109
Number of pages7
JournalJournal of Physical Chemistry C
Volume120
Issue number38
DOIs
Publication statusPublished - Sep 29 2016

Fingerprint

Gold
Contrast Media
magnetic resonance
gold
Nanoparticles
nanoparticles
Magnetic resonance
Imaging techniques
Polydispersity
Magnetic Resonance Imaging
Transmission electron microscopy
transmission electron microscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Surfaces, Coatings and Films
  • Physical and Theoretical Chemistry

Cite this

Shape-Dependent Relaxivity of Nanoparticle-Based T1 Magnetic Resonance Imaging Contrast Agents. / Culver, Kayla S B; Shin, Yu Jin; Rotz, Matthew W.; Meade, Thomas J.; Hersam, Mark C; Odom, Teri W.

In: Journal of Physical Chemistry C, Vol. 120, No. 38, 29.09.2016, p. 22103-22109.

Research output: Contribution to journalArticle

Culver, Kayla S B ; Shin, Yu Jin ; Rotz, Matthew W. ; Meade, Thomas J. ; Hersam, Mark C ; Odom, Teri W. / Shape-Dependent Relaxivity of Nanoparticle-Based T1 Magnetic Resonance Imaging Contrast Agents. In: Journal of Physical Chemistry C. 2016 ; Vol. 120, No. 38. pp. 22103-22109.
@article{0018ca7c6b9f468881108774ea02c9ab,
title = "Shape-Dependent Relaxivity of Nanoparticle-Based T1 Magnetic Resonance Imaging Contrast Agents",
abstract = "Gold nanostars functionalized with Gd(III) have shown significant promise as contrast agents for magnetic resonance imaging (MRI) because of their anisotropic, branched shape. However, the size and shape polydispersity of as-synthesized gold nanostars have precluded efforts to develop a rigorous relationship between the gold nanostar structure (e.g., number of branches) and relaxivity of surface-bound Gd(III). This paper describes the use of a centrifugal separation method that can produce structurally refined populations of gold nanostars and is compatible with Gd(III) functionalization. Combined transmission electron microscopy and relaxivity analyses revealed that the increased number of nanostar branches was correlated with enhanced relaxivity. By identifying the underlying relaxivity mechanisms for Gd(III)-functionalized gold nanostars, we can inform the design of high-performance MRI contrast agents.",
author = "Culver, {Kayla S B} and Shin, {Yu Jin} and Rotz, {Matthew W.} and Meade, {Thomas J.} and Hersam, {Mark C} and Odom, {Teri W}",
year = "2016",
month = "9",
day = "29",
doi = "10.1021/acs.jpcc.6b08362",
language = "English",
volume = "120",
pages = "22103--22109",
journal = "Journal of Physical Chemistry C",
issn = "1932-7447",
publisher = "American Chemical Society",
number = "38",

}

TY - JOUR

T1 - Shape-Dependent Relaxivity of Nanoparticle-Based T1 Magnetic Resonance Imaging Contrast Agents

AU - Culver, Kayla S B

AU - Shin, Yu Jin

AU - Rotz, Matthew W.

AU - Meade, Thomas J.

AU - Hersam, Mark C

AU - Odom, Teri W

PY - 2016/9/29

Y1 - 2016/9/29

N2 - Gold nanostars functionalized with Gd(III) have shown significant promise as contrast agents for magnetic resonance imaging (MRI) because of their anisotropic, branched shape. However, the size and shape polydispersity of as-synthesized gold nanostars have precluded efforts to develop a rigorous relationship between the gold nanostar structure (e.g., number of branches) and relaxivity of surface-bound Gd(III). This paper describes the use of a centrifugal separation method that can produce structurally refined populations of gold nanostars and is compatible with Gd(III) functionalization. Combined transmission electron microscopy and relaxivity analyses revealed that the increased number of nanostar branches was correlated with enhanced relaxivity. By identifying the underlying relaxivity mechanisms for Gd(III)-functionalized gold nanostars, we can inform the design of high-performance MRI contrast agents.

AB - Gold nanostars functionalized with Gd(III) have shown significant promise as contrast agents for magnetic resonance imaging (MRI) because of their anisotropic, branched shape. However, the size and shape polydispersity of as-synthesized gold nanostars have precluded efforts to develop a rigorous relationship between the gold nanostar structure (e.g., number of branches) and relaxivity of surface-bound Gd(III). This paper describes the use of a centrifugal separation method that can produce structurally refined populations of gold nanostars and is compatible with Gd(III) functionalization. Combined transmission electron microscopy and relaxivity analyses revealed that the increased number of nanostar branches was correlated with enhanced relaxivity. By identifying the underlying relaxivity mechanisms for Gd(III)-functionalized gold nanostars, we can inform the design of high-performance MRI contrast agents.

UR - http://www.scopus.com/inward/record.url?scp=84989836465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989836465&partnerID=8YFLogxK

U2 - 10.1021/acs.jpcc.6b08362

DO - 10.1021/acs.jpcc.6b08362

M3 - Article

VL - 120

SP - 22103

EP - 22109

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

SN - 1932-7447

IS - 38

ER -