Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures

Tyson J. Moyer, Hussein A. Kassam, Edward S.M. Bahnson, Courtney E. Morgan, Faifan Tantakitti, Teng L. Chew, Melina R. Kibbe, Samuel I. Stupp

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44 Citations (Scopus)

Abstract

Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.

Original languageEnglish
Pages (from-to)2750-2755
Number of pages6
JournalSmall
Volume11
Issue number23
DOIs
Publication statusPublished - Jun 1 2015

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Keywords

  • peptides
  • self-assembly
  • supramolecular chemistry
  • vascular targeting

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Moyer, T. J., Kassam, H. A., Bahnson, E. S. M., Morgan, C. E., Tantakitti, F., Chew, T. L., Kibbe, M. R., & Stupp, S. I. (2015). Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures. Small, 11(23), 2750-2755. https://doi.org/10.1002/smll.201403429