Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures

Tyson J. Moyer; Hussein A. Kassam; Edward S.M. Bahnson; Courtney E. Morgan; Faifan Tantakitti; Teng L. Chew; Melina R. Kibbe; Samuel I. Stupp

doi:10.1002/smll.201403429

Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures

Tyson J. Moyer, Hussein A. Kassam, Edward S.M. Bahnson, Courtney E. Morgan, Faifan Tantakitti, Teng L. Chew, Melina R. Kibbe, Samuel I. Stupp

Northwestern University

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.

Original language	English
Pages (from-to)	2750-2755
Number of pages	6
Journal	Small
Volume	11
Issue number	23
DOIs	https://doi.org/10.1002/smll.201403429
Publication status	Published - Jun 1 2015

Keywords

peptides
self-assembly
supramolecular chemistry
vascular targeting

ASJC Scopus subject areas

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

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10.1002/smll.201403429

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Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures. / Moyer, Tyson J.; Kassam, Hussein A.; Bahnson, Edward S.M.; Morgan, Courtney E.; Tantakitti, Faifan; Chew, Teng L.; Kibbe, Melina R.; Stupp, Samuel I.

In: Small, Vol. 11, No. 23, 01.06.2015, p. 2750-2755.

Research output: Contribution to journal › Article › peer-review

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abstract = "Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.",

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AU - Moyer, Tyson J.

AU - Kassam, Hussein A.

AU - Bahnson, Edward S.M.

AU - Morgan, Courtney E.

AU - Tantakitti, Faifan

AU - Chew, Teng L.

AU - Kibbe, Melina R.

AU - Stupp, Samuel I.

PY - 2015/6/1

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N2 - Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.

AB - Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.

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KW - self-assembly

KW - supramolecular chemistry

KW - vascular targeting

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Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures

Abstract

Keywords

ASJC Scopus subject areas

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