Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures

Tyson J. Moyer, Hussein A. Kassam, Edward S.M. Bahnson, Courtney E. Morgan, Faifan Tantakitti, Teng L. Chew, Melina R. Kibbe, Samuel I Stupp

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.

Original languageEnglish
Pages (from-to)2750-2755
Number of pages6
JournalSmall
Volume11
Issue number23
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Amphiphiles
Nanostructures
Blood vessels
Peptides
Blood Vessels
Nanofibers
Balloon Angioplasty
Balloons
Fluorescence
Binding Sites
Wounds and Injuries

Keywords

  • peptides
  • self-assembly
  • supramolecular chemistry
  • vascular targeting

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology

Cite this

Moyer, T. J., Kassam, H. A., Bahnson, E. S. M., Morgan, C. E., Tantakitti, F., Chew, T. L., ... Stupp, S. I. (2015). Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures. Small, 11(23), 2750-2755. https://doi.org/10.1002/smll.201403429

Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures. / Moyer, Tyson J.; Kassam, Hussein A.; Bahnson, Edward S.M.; Morgan, Courtney E.; Tantakitti, Faifan; Chew, Teng L.; Kibbe, Melina R.; Stupp, Samuel I.

In: Small, Vol. 11, No. 23, 01.06.2015, p. 2750-2755.

Research output: Contribution to journalArticle

Moyer, TJ, Kassam, HA, Bahnson, ESM, Morgan, CE, Tantakitti, F, Chew, TL, Kibbe, MR & Stupp, SI 2015, 'Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures', Small, vol. 11, no. 23, pp. 2750-2755. https://doi.org/10.1002/smll.201403429
Moyer TJ, Kassam HA, Bahnson ESM, Morgan CE, Tantakitti F, Chew TL et al. Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures. Small. 2015 Jun 1;11(23):2750-2755. https://doi.org/10.1002/smll.201403429
Moyer, Tyson J. ; Kassam, Hussein A. ; Bahnson, Edward S.M. ; Morgan, Courtney E. ; Tantakitti, Faifan ; Chew, Teng L. ; Kibbe, Melina R. ; Stupp, Samuel I. / Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures. In: Small. 2015 ; Vol. 11, No. 23. pp. 2750-2755.
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