Simple and compelling biomimetic metal-organic framework catalyst for the degradation of nerve agent simulants

Michael J. Katz, Joseph E. Mondloch, Ryan K. Totten, Jin K. Park, Sonbinh T. Nguyen, Omar K. Farha, Joseph T. Hupp

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Inspired by biology, in which a bimetallic hydroxide-bridged zinc(II)-containing enzyme is utilized to catalytically hydrolyze phosphate ester bonds, the utility of a zirconium(IV)-cluster-containing metal-organic framework as a catalyst for the methanolysis and hydrolysis of phosphate-based nerve agent simulants was examined. The combination of the strong Lewis-acidic ZrIV and bridging hydroxide anions led to ultrafast half-lives for these solvolysis reactions. This is especially remarkable considering that the actual catalyst loading was a mere 0.045 % as a result of the surface-only catalysis observed. Nervous breakdown: UiO-66, a biomimetic metal-organic framework based on a zirconium oxo cluster, is capable of rapidly catalyzing the breakdown of phosphate-based nerve agent simulants. UiO-66 catalyzes both methanolysis and hydrolysis of the nerve agent simulant methyl paraoxon (shown in the graphic, R=CH3) with high catalytic efficiency.

Original languageEnglish
Pages (from-to)497-501
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number2
DOIs
Publication statusPublished - Jan 7 2014

Keywords

  • coordination polymers
  • heterogeneous catalysis
  • hydrolysis
  • metal-organic frameworks
  • nerve agents

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Simple and compelling biomimetic metal-organic framework catalyst for the degradation of nerve agent simulants'. Together they form a unique fingerprint.

  • Cite this