Simple and efficient catalytic reaction for the selective deuteration of alcohols

Eugene Khaskin; David Milstein

doi:10.1021/cs400092p

Simple and efficient catalytic reaction for the selective deuteration of alcohols

Eugene Khaskin, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

A highly efficient system for the catalytic deuteration of α and β CH bonds of primary and secondary alcohols has been developed. The deuterium source is D₂O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d₆. The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.

Original language	English
Pages (from-to)	448-452
Number of pages	5
Journal	ACS Catalysis
Volume	3
Issue number	3
DOIs	https://doi.org/10.1021/cs400092p
Publication status	Published - Mar 11 2013

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Keywords

DO
H/D exchange
Ru pincer catalyst
alcohols
homogeneous catalysis
selective deuteration

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Cite this

Khaskin, E., & Milstein, D. (2013). Simple and efficient catalytic reaction for the selective deuteration of alcohols. ACS Catalysis, 3(3), 448-452. https://doi.org/10.1021/cs400092p

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Access to Document

10.1021/cs400092p