Abstract
A highly efficient system for the catalytic deuteration of α and β CH bonds of primary and secondary alcohols has been developed. The deuterium source is D2O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d6. The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.
| Original language | English |
|---|---|
| Pages (from-to) | 448-452 |
| Number of pages | 5 |
| Journal | ACS Catalysis |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 11 2013 |
Keywords
- DO
- H/D exchange
- Ru pincer catalyst
- alcohols
- homogeneous catalysis
- selective deuteration
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Cite this
Khaskin, E., & Milstein, D. (2013). Simple and efficient catalytic reaction for the selective deuteration of alcohols. ACS Catalysis, 3(3), 448-452. https://doi.org/10.1021/cs400092p