Abstract
A highly efficient system for the catalytic deuteration of α and β CH bonds of primary and secondary alcohols has been developed. The deuterium source is D2O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d6. The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.
| Original language | English |
|---|---|
| Pages (from-to) | 448-452 |
| Number of pages | 5 |
| Journal | ACS Catalysis |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- alcohols
- DO
- H/D exchange
- homogeneous catalysis
- Ru pincer catalyst
- selective deuteration
ASJC Scopus subject areas
- Catalysis
Cite this
Simple and efficient catalytic reaction for the selective deuteration of alcohols. / Khaskin, Eugene; Milstein, David.
In: ACS Catalysis, Vol. 3, No. 3, 2013, p. 448-452.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simple and efficient catalytic reaction for the selective deuteration of alcohols
AU - Khaskin, Eugene
AU - Milstein, David
PY - 2013
Y1 - 2013
N2 - A highly efficient system for the catalytic deuteration of α and β CH bonds of primary and secondary alcohols has been developed. The deuterium source is D2O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d6. The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.
AB - A highly efficient system for the catalytic deuteration of α and β CH bonds of primary and secondary alcohols has been developed. The deuterium source is D2O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d6. The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.
KW - alcohols
KW - DO
KW - H/D exchange
KW - homogeneous catalysis
KW - Ru pincer catalyst
KW - selective deuteration
UR - http://www.scopus.com/inward/record.url?scp=84874643729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874643729&partnerID=8YFLogxK
U2 - 10.1021/cs400092p
DO - 10.1021/cs400092p
M3 - Article
AN - SCOPUS:84874643729
VL - 3
SP - 448
EP - 452
JO - ACS Catalysis
JF - ACS Catalysis
SN - 2155-5435
IS - 3
ER -