Simple and efficient catalytic reaction for the selective deuteration of alcohols

Eugene Khaskin, David Milstein

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


A highly efficient system for the catalytic deuteration of α and β CH bonds of primary and secondary alcohols has been developed. The deuterium source is D2O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d6. The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.

Original languageEnglish
Pages (from-to)448-452
Number of pages5
JournalACS Catalysis
Issue number3
Publication statusPublished - Mar 2013


  • H/D exchange
  • Ru pincer catalyst
  • alcohols
  • homogeneous catalysis
  • selective deuteration

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Simple and efficient catalytic reaction for the selective deuteration of alcohols'. Together they form a unique fingerprint.

Cite this