Simultaneous self-assembly, orientation, and patterning of peptide-amphiphile nanofibers by soft lithography

Albert M. Hungt, Samuel I Stupp

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Self-assembled nanofibers of peptide-amphiphile molecules have been of great interest because of their bioactivity both in vitro and in vivo. In this work, we demonstrate the simultaneous self-assembly, alignment, and patterning of these nanofibers over large areas by a novel technique termed sonication-assisted solution embossing. In this soft lithographic technique, the nanostructures self-assemble by solvent evaporation while under the influence of ultrasonic agitation and confinement within the topographical features of an elastomeric stamp. The nanofibers orient parallel to the channels as they assemble out of solution, yielding bundles of aligned nanofibers on the substrate after the stamp is removed. Alignment is likely a result of steric confinement and possibly a transition to a lyotropic liquid crystalline phase as solvent evaporates. This technique is not limited to uniaxial alignment and is shown to be able to guide nanofibers around turns. Alignment of nanostructures by this method introduces the possibility of controlling macroscale cellular behavior or material properties by tuning the directionality of interactions at the nanoscale.

Original languageEnglish
Pages (from-to)1165-1171
Number of pages7
JournalNano Letters
Volume7
Issue number5
DOIs
Publication statusPublished - May 2007

Fingerprint

Amphiphiles
Nanofibers
Self assembly
Lithography
Peptides
peptides
self assembly
lithography
alignment
ultrasonic agitation
Nanostructures
embossing
Sonication
bundles
Bioactivity
tuning
evaporation
Materials properties
Evaporation
Tuning

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Simultaneous self-assembly, orientation, and patterning of peptide-amphiphile nanofibers by soft lithography. / Hungt, Albert M.; Stupp, Samuel I.

In: Nano Letters, Vol. 7, No. 5, 05.2007, p. 1165-1171.

Research output: Contribution to journalArticle

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