Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy

Alyssa B. Zrimsek, Naihao Chiang, Michael Mattei, Stephanie Zaleski, Michael O. McAnally, Craig T. Chapman, Anne Isabelle Henry, George C Schatz, Richard P. Van Duyne

Research output: Contribution to journalReview article

125 Citations (Scopus)

Abstract

Single-molecule (SM) surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS) have emerged as analytical techniques for characterizing molecular systems in nanoscale environments. SERS and TERS use plasmonically enhanced Raman scattering to characterize the chemical information on single molecules. Additionally, TERS can image single molecules with subnanometer spatial resolution. In this review, we cover the development and history of SERS and TERS, including the concept of SERS hot spots and the plasmonic nanostructures necessary for SM detection, the past and current methodologies for verifying SMSERS, and investigations into understanding the signal heterogeneities observed with SMSERS. Moving on to TERS, we cover tip fabrication and the physical origins of the subnanometer spatial resolution. Then, we highlight recent advances of SMSERS and TERS in fields such as electrochemistry, catalysis, and SM electronics, which all benefit from the vibrational characterization of single molecules. SMSERS and TERS provide new insights on molecular behavior that would otherwise be obscured in an ensemble-averaged measurement.

Original languageEnglish
Pages (from-to)7583-7613
Number of pages31
JournalChemical Reviews
Volume117
Issue number11
DOIs
Publication statusPublished - Jun 14 2017

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Raman spectroscopy
Molecules
Electrochemistry
Catalysis
Raman scattering
Nanostructures
Electronic equipment
Fabrication

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Zrimsek, A. B., Chiang, N., Mattei, M., Zaleski, S., McAnally, M. O., Chapman, C. T., ... Van Duyne, R. P. (2017). Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy. Chemical Reviews, 117(11), 7583-7613. https://doi.org/10.1021/acs.chemrev.6b00552

Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy. / Zrimsek, Alyssa B.; Chiang, Naihao; Mattei, Michael; Zaleski, Stephanie; McAnally, Michael O.; Chapman, Craig T.; Henry, Anne Isabelle; Schatz, George C; Van Duyne, Richard P.

In: Chemical Reviews, Vol. 117, No. 11, 14.06.2017, p. 7583-7613.

Research output: Contribution to journalReview article

Zrimsek, AB, Chiang, N, Mattei, M, Zaleski, S, McAnally, MO, Chapman, CT, Henry, AI, Schatz, GC & Van Duyne, RP 2017, 'Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy', Chemical Reviews, vol. 117, no. 11, pp. 7583-7613. https://doi.org/10.1021/acs.chemrev.6b00552
Zrimsek AB, Chiang N, Mattei M, Zaleski S, McAnally MO, Chapman CT et al. Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy. Chemical Reviews. 2017 Jun 14;117(11):7583-7613. https://doi.org/10.1021/acs.chemrev.6b00552
Zrimsek, Alyssa B. ; Chiang, Naihao ; Mattei, Michael ; Zaleski, Stephanie ; McAnally, Michael O. ; Chapman, Craig T. ; Henry, Anne Isabelle ; Schatz, George C ; Van Duyne, Richard P. / Single-Molecule Chemistry with Surface- and Tip-Enhanced Raman Spectroscopy. In: Chemical Reviews. 2017 ; Vol. 117, No. 11. pp. 7583-7613.
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