Single-walled Carbon Nanotubes Are a New Class of Ion Channel Blockers

Ki Ho Park, Manish Chhowalla, Zafar Iqbal, Federico Sesti

Research output: Contribution to journalArticle

253 Citations (Scopus)

Abstract

Here we identify a novel class of biological membrane ion channel blockers called single-walled carbon nanotubes (SWNTs). SWNTs with diameter distributions peaked at ∼0.9 and 1.3 nm, C60 fullerenes, multi wall nanotubes (MWNTs), and hyperfullerenes (nano-"onions") were synthesized by several techniques and applied to diverse channel types heterologously expressed in mammalian cells. External as-fabricated and purified SWNTs blocked K+ channel subunits in a dose-dependent manner. Blockage was dependent on the shape and dimensions of the nanoparticles used and did not require any electrochemical interaction. SWNTs were more effective than the spherical fullerenes and, for both, diameter was the determining factor. These findings postulate new uses for SWNTs in biological applications and provide unexpected insights into the current view of mechanisms governing the interaction of ion channels with blocking molecules.

Original languageEnglish
Pages (from-to)50212-50216
Number of pages5
JournalJournal of Biological Chemistry
Volume278
Issue number50
DOIs
Publication statusPublished - Dec 12 2003

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Carbon Nanotubes
Single-walled carbon nanotubes (SWCN)
Ion Channels
Fullerenes
Biological membranes
Nanotubes
Onions
Nanoparticles
Cells
Molecules

ASJC Scopus subject areas

  • Biochemistry

Cite this

Single-walled Carbon Nanotubes Are a New Class of Ion Channel Blockers. / Park, Ki Ho; Chhowalla, Manish; Iqbal, Zafar; Sesti, Federico.

In: Journal of Biological Chemistry, Vol. 278, No. 50, 12.12.2003, p. 50212-50216.

Research output: Contribution to journalArticle

Park, Ki Ho ; Chhowalla, Manish ; Iqbal, Zafar ; Sesti, Federico. / Single-walled Carbon Nanotubes Are a New Class of Ion Channel Blockers. In: Journal of Biological Chemistry. 2003 ; Vol. 278, No. 50. pp. 50212-50216.
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