Smaller CpG-conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation

Jun Yue, Roger M. Pallares, Lisa Cole, Emma E. Coughlin, Chad A. Mirkin, Andrew Lee, Teri W Odom

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This paper describes a side-by-side comparison of the in vitro immunostimulatory activity of CpG-conjugated gold nanoparticles. Three different gold nanoparticle cores (13-nm spheres, 50-nm spheres, and 40-nm stars) with the same CpG surface density were investigated for toll-like receptor 9 activation. For this parameter set, 13-nm spheres displayed significantly higher specificity for targeting immune receptors and larger nanoparticles (50-nm spheres and 40-nm stars) showed higher cellular uptake and higher immune activation because of off-target effects. Changes in nanoparticle size and presentation of activating ligands affect construct-induced immune responses at different levels, and care must be taken when considering practical and global design rules for CpG delivery.

Original languageEnglish
JournalACS Applied Materials and Interfaces
DOIs
Publication statusAccepted/In press - Apr 23 2018

Fingerprint

Gold
Chemical activation
Nanoparticles
Stars
Toll-Like Receptor 9
Ligands

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Smaller CpG-conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation. / Yue, Jun; Pallares, Roger M.; Cole, Lisa; Coughlin, Emma E.; Mirkin, Chad A.; Lee, Andrew; Odom, Teri W.

In: ACS Applied Materials and Interfaces, 23.04.2018.

Research output: Contribution to journalArticle

Yue, Jun ; Pallares, Roger M. ; Cole, Lisa ; Coughlin, Emma E. ; Mirkin, Chad A. ; Lee, Andrew ; Odom, Teri W. / Smaller CpG-conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation. In: ACS Applied Materials and Interfaces. 2018.
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