Solvent Reorganization Energy of Charge Transfer in DNA Hairpins

David N. LeBard, Mark Lilichenko, Dmitry V. Matyushov, Yuri A. Berlin, Mark A Ratner

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

We report calculations of solvent reorganization energies and the energy gap analysis for charge transfer in synthetic DNA hairpins consisting of two complementary strands linked by a stilbene chromophore. Reorganization energies are calculated for the processes of photoinduced hole injection from the linker to a neighboring guanine (G) through variable numbers of adenine/thymine (AT) pairs and for the hole transfer between adjacent G sites connected by AT bridges of different length. Twelve molecules with varying donor-acceptor separation have been analyzed. The solute structure is taken from crystallographic data with atomic resolution, and the polarization response of water is modeled in terms of polarization structure factors accounting for the molecular nature of the polarization fluctuations of the solvent. Both the magnitudes of reorganization energies and the parameter of the rate constant falloff with the donor-acceptor separation turn out to be much higher than those obtained from the Marcus-Levich-Jortner analysis of the experimental kinetic data. The discrepancy is resolved by applying a new model (Q-model) of charge-transfer accounting for different reorganization energies for charge separation and charge recombination reactions.

Original languageEnglish
Pages (from-to)14509-14520
Number of pages12
JournalJournal of Physical Chemistry B
Volume107
Issue number51
Publication statusPublished - Dec 25 2003

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Charge transfer
DNA
Thymine
deoxyribonucleic acid
charge transfer
Adenine
Polarization
thymine
adenines
Stilbenes
polarization
Guanine
Chromophores
recombination reactions
stilbene
energy
guanines
Rate constants
Energy gap
polarization (charge separation)

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

LeBard, D. N., Lilichenko, M., Matyushov, D. V., Berlin, Y. A., & Ratner, M. A. (2003). Solvent Reorganization Energy of Charge Transfer in DNA Hairpins. Journal of Physical Chemistry B, 107(51), 14509-14520.

Solvent Reorganization Energy of Charge Transfer in DNA Hairpins. / LeBard, David N.; Lilichenko, Mark; Matyushov, Dmitry V.; Berlin, Yuri A.; Ratner, Mark A.

In: Journal of Physical Chemistry B, Vol. 107, No. 51, 25.12.2003, p. 14509-14520.

Research output: Contribution to journalArticle

LeBard, DN, Lilichenko, M, Matyushov, DV, Berlin, YA & Ratner, MA 2003, 'Solvent Reorganization Energy of Charge Transfer in DNA Hairpins', Journal of Physical Chemistry B, vol. 107, no. 51, pp. 14509-14520.
LeBard DN, Lilichenko M, Matyushov DV, Berlin YA, Ratner MA. Solvent Reorganization Energy of Charge Transfer in DNA Hairpins. Journal of Physical Chemistry B. 2003 Dec 25;107(51):14509-14520.
LeBard, David N. ; Lilichenko, Mark ; Matyushov, Dmitry V. ; Berlin, Yuri A. ; Ratner, Mark A. / Solvent Reorganization Energy of Charge Transfer in DNA Hairpins. In: Journal of Physical Chemistry B. 2003 ; Vol. 107, No. 51. pp. 14509-14520.
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