Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures

Rahul Chhabra, Jaswinder Sharma, Yonggang Ke, Yan Liu, Sherri Rinker, Stuart Lindsay, Hao Yan

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.

Original languageEnglish
Pages (from-to)10304-10305
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number34
DOIs
Publication statusPublished - Aug 29 2007

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Nucleotide Aptamers
Protein Array Analysis
Tissue Engineering
Proteomics
DNA
Proteins
Bioelectric potentials
Tissue engineering

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures. / Chhabra, Rahul; Sharma, Jaswinder; Ke, Yonggang; Liu, Yan; Rinker, Sherri; Lindsay, Stuart; Yan, Hao.

In: Journal of the American Chemical Society, Vol. 129, No. 34, 29.08.2007, p. 10304-10305.

Research output: Contribution to journalArticle

Chhabra, Rahul ; Sharma, Jaswinder ; Ke, Yonggang ; Liu, Yan ; Rinker, Sherri ; Lindsay, Stuart ; Yan, Hao. / Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures. In: Journal of the American Chemical Society. 2007 ; Vol. 129, No. 34. pp. 10304-10305.
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