Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures

Rahul Chhabra, Jaswinder Sharma, Yonggang Ke, Yan Liu, Sherri Rinker, Stuart Lindsay, Hao Yan

Research output: Contribution to journalArticlepeer-review

213 Citations (Scopus)

Abstract

Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.

Original languageEnglish
Pages (from-to)10304-10305
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number34
DOIs
Publication statusPublished - Aug 29 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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