Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework

Alysia Lowe, Punya Chittajallu, Qihan Gong, Jing Li, Kenneth J. Balkus

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Metal-organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H6TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 μmol/g NO by exposure to 85% humidity and 53 μmol/g NO by heating to 37 C.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalMicroporous and Mesoporous Materials
Publication statusPublished - Aug 13 2013


  • Diazeniumdiolate
  • Metal organic framework
  • Nitric oxide
  • Wound healing

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials

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