Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework

Alysia Lowe, Punya Chittajallu, Qihan Gong, Jing Li, Kenneth J. Balkus

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Metal-organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H6TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 μmol/g NO by exposure to 85% humidity and 53 μmol/g NO by heating to 37 C.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalMicroporous and Mesoporous Materials
Volume181
DOIs
Publication statusPublished - 2013

Fingerprint

Nitric oxide
nitric oxide
delivery
Nitric Oxide
Metals
metals
Triazines
Gas adsorption
Nitric Oxide Donors
Amines
Copper
Atmospheric humidity
humidity
amines
Heating
copper
adsorption
heating
gases

Keywords

  • Diazeniumdiolate
  • Metal organic framework
  • Nitric oxide
  • Wound healing

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework. / Lowe, Alysia; Chittajallu, Punya; Gong, Qihan; Li, Jing; Balkus, Kenneth J.

In: Microporous and Mesoporous Materials, Vol. 181, 2013, p. 17-22.

Research output: Contribution to journalArticle

Lowe, Alysia ; Chittajallu, Punya ; Gong, Qihan ; Li, Jing ; Balkus, Kenneth J. / Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework. In: Microporous and Mesoporous Materials. 2013 ; Vol. 181. pp. 17-22.
@article{54c6053b415f487bbff40e87b6dff3a9,
title = "Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework",
abstract = "Metal-organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H6TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 μmol/g NO by exposure to 85{\%} humidity and 53 μmol/g NO by heating to 37 C.",
keywords = "Diazeniumdiolate, Metal organic framework, Nitric oxide, Wound healing",
author = "Alysia Lowe and Punya Chittajallu and Qihan Gong and Jing Li and Balkus, {Kenneth J.}",
year = "2013",
doi = "10.1016/j.micromeso.2013.07.017",
language = "English",
volume = "181",
pages = "17--22",
journal = "Microporous and Mesoporous Materials",
issn = "1387-1811",
publisher = "Elsevier",

}

TY - JOUR

T1 - Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework

AU - Lowe, Alysia

AU - Chittajallu, Punya

AU - Gong, Qihan

AU - Li, Jing

AU - Balkus, Kenneth J.

PY - 2013

Y1 - 2013

N2 - Metal-organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H6TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 μmol/g NO by exposure to 85% humidity and 53 μmol/g NO by heating to 37 C.

AB - Metal-organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H6TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 μmol/g NO by exposure to 85% humidity and 53 μmol/g NO by heating to 37 C.

KW - Diazeniumdiolate

KW - Metal organic framework

KW - Nitric oxide

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=84881236382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881236382&partnerID=8YFLogxK

U2 - 10.1016/j.micromeso.2013.07.017

DO - 10.1016/j.micromeso.2013.07.017

M3 - Article

VL - 181

SP - 17

EP - 22

JO - Microporous and Mesoporous Materials

JF - Microporous and Mesoporous Materials

SN - 1387-1811

ER -