Structural optimization of Zn(II)-activated magnetic resonance imaging probes

Lauren M. Matosziuk, Jonathan H. Leibowitz, Marie C. Heffern, Keith W. Macrenaris, Mark A Ratner, Thomas J. Meade

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We report the structural optimization and mechanistic investigation of a series of bioactivated magnetic resonance imaging contrast agents that transform from low relaxivity to high relaxivity in the presence of Zn(II). The change in relaxivity results from a structural transformation of the complex that alters the coordination environment about the Gd(III) center. Here, we have performed a series of systematic modifications to determine the structure that provides the optimal change in relaxivity in response to the presence of Zn(II). Relaxivity measurements in the presence and absence of Zn(II) were used in conjunction with measurements regarding water access (namely, number of water molecules bound) to the Gd(III) center and temperature-dependent 13C NMR spectroscopy to determine how the coordination environment about the Gd(III) center is affected by the distance between the Zn(II)-binding domain and the Gd(III) chelate, the number of functional groups on the Zn(II)-binding domain, and the presence of Zn(II). The results of this study provide valuable insight into the design principles for future bioactivated magnetic resonance probes.

Original languageEnglish
Pages (from-to)12250-12261
Number of pages12
JournalInorganic Chemistry
Volume52
Issue number21
DOIs
Publication statusPublished - Nov 4 2013

Fingerprint

Structural optimization
Magnetic resonance
magnetic resonance
Imaging techniques
optimization
Water
probes
resonance probes
Contrast Media
Functional groups
Nuclear magnetic resonance spectroscopy
chelates
water
Molecules
nuclear magnetic resonance
Temperature
spectroscopy
molecules
temperature

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Matosziuk, L. M., Leibowitz, J. H., Heffern, M. C., Macrenaris, K. W., Ratner, M. A., & Meade, T. J. (2013). Structural optimization of Zn(II)-activated magnetic resonance imaging probes. Inorganic Chemistry, 52(21), 12250-12261. https://doi.org/10.1021/ic400681j

Structural optimization of Zn(II)-activated magnetic resonance imaging probes. / Matosziuk, Lauren M.; Leibowitz, Jonathan H.; Heffern, Marie C.; Macrenaris, Keith W.; Ratner, Mark A; Meade, Thomas J.

In: Inorganic Chemistry, Vol. 52, No. 21, 04.11.2013, p. 12250-12261.

Research output: Contribution to journalArticle

Matosziuk, LM, Leibowitz, JH, Heffern, MC, Macrenaris, KW, Ratner, MA & Meade, TJ 2013, 'Structural optimization of Zn(II)-activated magnetic resonance imaging probes', Inorganic Chemistry, vol. 52, no. 21, pp. 12250-12261. https://doi.org/10.1021/ic400681j
Matosziuk LM, Leibowitz JH, Heffern MC, Macrenaris KW, Ratner MA, Meade TJ. Structural optimization of Zn(II)-activated magnetic resonance imaging probes. Inorganic Chemistry. 2013 Nov 4;52(21):12250-12261. https://doi.org/10.1021/ic400681j
Matosziuk, Lauren M. ; Leibowitz, Jonathan H. ; Heffern, Marie C. ; Macrenaris, Keith W. ; Ratner, Mark A ; Meade, Thomas J. / Structural optimization of Zn(II)-activated magnetic resonance imaging probes. In: Inorganic Chemistry. 2013 ; Vol. 52, No. 21. pp. 12250-12261.
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