Structures of DNA-linked nanoparticle aggregates

Sung Yong Park, Jae Seung Lee, Dimitra Georganopoulou, Chad A. Mirkin, George C Schatz

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The room-temperature structure of DNA-linked gold nanoparticle aggregates is investigated using a combination of experiment and theory. The experiments involve extinction spectroscopy measurements and dynamic light scattering measurements of aggregates made using 60 and 80 nm gold particles and 30 base-pair DNA. The theoretical studies use calculated spectra for models of the aggregate structures to determine which structure matches the observations. These models include diffusion-limited cluster-cluster aggregation (DLCA), reaction-̀limited cluster-cluster aggregation (RLCA), and compact (nonfractal) cluster aggregation. The diameter of the nanoparticles used in the experiments is larger than has been considered previously, and this provides greater sensitivity of spectra to aggregate structure. We show that the best match between experiment and theory occurs for the RLCA fractal structures. This indicates that DNA hybridization takes place under irreversible conditions in the room-temperature aggregation. Some possible structural variations which might influence the result are considered, including the edge-to-edge distance between nanoparticles, variation in the diameter of the nanoparticles, underlying lattice structures of on-lattice compact clusters, and positional disorders in the lattice structures. We find that these variations do not change the conclusion that the room-temperature structure of the aggregates is fractal. We also examine the variation in extinction at 260 nm as temperature is increased, showing that the decrease in extinction at temperatures below the melting temperature is related to a morphological change from fractal toward compact structures.

Original languageEnglish
Pages (from-to)12673-12681
Number of pages9
JournalJournal of Physical Chemistry B
Volume110
Issue number25
DOIs
Publication statusPublished - Jun 29 2006

Fingerprint

DNA
Agglomeration
deoxyribonucleic acid
Nanoparticles
nanoparticles
Fractals
Gold
fractals
Temperature
extinction
Experiments
Light extinction
Dynamic light scattering
room temperature
Melting point
gold
Spectroscopy
temperature
light scattering
melting

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Park, S. Y., Lee, J. S., Georganopoulou, D., Mirkin, C. A., & Schatz, G. C. (2006). Structures of DNA-linked nanoparticle aggregates. Journal of Physical Chemistry B, 110(25), 12673-12681. https://doi.org/10.1021/jp062212+

Structures of DNA-linked nanoparticle aggregates. / Park, Sung Yong; Lee, Jae Seung; Georganopoulou, Dimitra; Mirkin, Chad A.; Schatz, George C.

In: Journal of Physical Chemistry B, Vol. 110, No. 25, 29.06.2006, p. 12673-12681.

Research output: Contribution to journalArticle

Park, SY, Lee, JS, Georganopoulou, D, Mirkin, CA & Schatz, GC 2006, 'Structures of DNA-linked nanoparticle aggregates', Journal of Physical Chemistry B, vol. 110, no. 25, pp. 12673-12681. https://doi.org/10.1021/jp062212+
Park SY, Lee JS, Georganopoulou D, Mirkin CA, Schatz GC. Structures of DNA-linked nanoparticle aggregates. Journal of Physical Chemistry B. 2006 Jun 29;110(25):12673-12681. https://doi.org/10.1021/jp062212+
Park, Sung Yong ; Lee, Jae Seung ; Georganopoulou, Dimitra ; Mirkin, Chad A. ; Schatz, George C. / Structures of DNA-linked nanoparticle aggregates. In: Journal of Physical Chemistry B. 2006 ; Vol. 110, No. 25. pp. 12673-12681.
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