Submolecular Gates Self-Assemble for Hot-Electron Transfer in Proteins

Neta Filip-Granit, Eran Goldberg, Ilan Samish, Idan Ashur, Milko van der Boom, Hagai Cohen, Avigdor Scherz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Redox reactions play key roles in fundamental biological processes. The related spatial organization of donors and acceptors is assumed to undergo evolutionary optimization facilitating charge mobilization within the relevant biological context. Experimental information from submolecular functional sites is needed to understand the organization strategies and driving forces involved in the self-development of structure-function relationships. Here we exploit chemically resolved electrical measurements (CREM) to probe the atom-specific electrostatic potentials (ESPs) in artificial arrays of bacteriochlorophyll (BChl) derivatives that provide model systems for photoexcited (hot) electron donation and withdrawal. On the basis of computations we show that native BChl's in the photosynthetic reaction center (RC) self-assemble at their ground-state as aligned gates for functional charge transfer. The combined computational and experimental results further reveal how site-specific polarizability perpendicular to the molecular plane enhances the hot-electron transport. Maximal transport efficiency is predicted for a specific, ∼5 Å, distance above the center of the metalized BChl, which is in remarkably close agreement with the distance and mutual orientation of corresponding native cofactors. These findings provide new metrics and guidelines for analysis of biological redox centers and for designing charge mobilizing machines such as artificial photosynthesis.

Original languageEnglish
Pages (from-to)6981-6988
Number of pages8
JournalJournal of Physical Chemistry B
Volume121
Issue number29
DOIs
Publication statusPublished - Jul 27 2017

Fingerprint

Bacteriochlorophylls
Hot electrons
hot electrons
electron transfer
Photosynthetic Reaction Center Complex Proteins
proteins
Proteins
Photosynthesis
Redox reactions
Ground state
Charge transfer
Electrostatics
photosynthesis
Derivatives
Atoms
electrical measurement
charge transfer
electrostatics
optimization
ground state

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Filip-Granit, N., Goldberg, E., Samish, I., Ashur, I., van der Boom, M., Cohen, H., & Scherz, A. (2017). Submolecular Gates Self-Assemble for Hot-Electron Transfer in Proteins. Journal of Physical Chemistry B, 121(29), 6981-6988. https://doi.org/10.1021/acs.jpcb.7b00432

Submolecular Gates Self-Assemble for Hot-Electron Transfer in Proteins. / Filip-Granit, Neta; Goldberg, Eran; Samish, Ilan; Ashur, Idan; van der Boom, Milko; Cohen, Hagai; Scherz, Avigdor.

In: Journal of Physical Chemistry B, Vol. 121, No. 29, 27.07.2017, p. 6981-6988.

Research output: Contribution to journalArticle

Filip-Granit, N, Goldberg, E, Samish, I, Ashur, I, van der Boom, M, Cohen, H & Scherz, A 2017, 'Submolecular Gates Self-Assemble for Hot-Electron Transfer in Proteins', Journal of Physical Chemistry B, vol. 121, no. 29, pp. 6981-6988. https://doi.org/10.1021/acs.jpcb.7b00432
Filip-Granit, Neta ; Goldberg, Eran ; Samish, Ilan ; Ashur, Idan ; van der Boom, Milko ; Cohen, Hagai ; Scherz, Avigdor. / Submolecular Gates Self-Assemble for Hot-Electron Transfer in Proteins. In: Journal of Physical Chemistry B. 2017 ; Vol. 121, No. 29. pp. 6981-6988.
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