Super-resolution enhancement by quantum image scanning microscopy

Ron Tenne, Uri Rossman, Batel Rephael, Yonatan Israel, Alexander Krupinski-Ptaszek, Radek Lapkiewicz, Yaron Silberberg, Dan Oron

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The principles of quantum optics have yielded a plethora of ideas to surpass the classical limitations of sensitivity and resolution in optical microscopy. While some ideas have been applied in proof-of-principle experiments, imaging a biological sample has remained challenging, mainly due to the inherently weak signal measured and the fragility of quantum states of light. In principle, however, these quantum protocols can add new information without sacrificing the classical information and can therefore enhance the capabilities of existing super-resolution techniques. Image scanning microscopy, a recent addition to the family of super-resolution methods, generates a robust resolution enhancement without reducing the signal level. Here, we introduce quantum image scanning microscopy: combining image scanning microscopy with the measurement of quantum photon correlation allows increasing the resolution of image scanning microscopy up to twofold, four times beyond the diffraction limit. We introduce the Q-ISM principle and obtain super-resolved optical images of a biological sample stained with fluorescent quantum dots using photon antibunching, a quantum effect, as a resolution-enhancing contrast mechanism.

Original languageEnglish
JournalNature Photonics
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Microscopic examination
microscopy
Scanning
scanning
augmentation
Photons
Quantum optics
Semiconductor quantum dots
Optical microscopy
quantum optics
Diffraction
photons
Imaging techniques
quantum dots
Experiments
sensitivity
diffraction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Tenne, R., Rossman, U., Rephael, B., Israel, Y., Krupinski-Ptaszek, A., Lapkiewicz, R., ... Oron, D. (Accepted/In press). Super-resolution enhancement by quantum image scanning microscopy. Nature Photonics. https://doi.org/10.1038/s41566-018-0324-z

Super-resolution enhancement by quantum image scanning microscopy. / Tenne, Ron; Rossman, Uri; Rephael, Batel; Israel, Yonatan; Krupinski-Ptaszek, Alexander; Lapkiewicz, Radek; Silberberg, Yaron; Oron, Dan.

In: Nature Photonics, 01.01.2018.

Research output: Contribution to journalArticle

Tenne, R, Rossman, U, Rephael, B, Israel, Y, Krupinski-Ptaszek, A, Lapkiewicz, R, Silberberg, Y & Oron, D 2018, 'Super-resolution enhancement by quantum image scanning microscopy', Nature Photonics. https://doi.org/10.1038/s41566-018-0324-z
Tenne R, Rossman U, Rephael B, Israel Y, Krupinski-Ptaszek A, Lapkiewicz R et al. Super-resolution enhancement by quantum image scanning microscopy. Nature Photonics. 2018 Jan 1. https://doi.org/10.1038/s41566-018-0324-z
Tenne, Ron ; Rossman, Uri ; Rephael, Batel ; Israel, Yonatan ; Krupinski-Ptaszek, Alexander ; Lapkiewicz, Radek ; Silberberg, Yaron ; Oron, Dan. / Super-resolution enhancement by quantum image scanning microscopy. In: Nature Photonics. 2018.
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