Supercritical antisolvent processing of γ-Indomethacin: Effects of solvent, concentration, pressure and temperature on SAS processed Indomethacin

Princy Varughese, Jing Li, Wayne Wang, Denita Winstead

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26 Citations (Scopus)

Abstract

γ-Indomethacin (IMC) is successfully processed with the supercritical antisolvent (SAS) technique. Pure, acicular (needle-like) particles of the α-polymorph are consistently obtained with SAS as the solvent, concentration, temperature and pressures are varied. Controlled changes in process parameters yield significant changes in particle size. Enhanced dissolution profiles are observed with IMC processed with SAS as opposed to the unprocessed IMC. The reduced particle size, as well as the α-polymorphic form of IMC, contributes to the enhanced dissolution rate.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalPowder Technology
Volume201
Issue number1
DOIs
Publication statusPublished - Jul 1 2010

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Keywords

  • Amorphous
  • Indomethacin
  • Micronization
  • Poor water solubility
  • Supercritical antisolvent processing

ASJC Scopus subject areas

  • Chemical Engineering(all)

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