Supramolecular crafting of cell adhesion

Hannah Storrie, Mustafa O. Guler, Suha N. Abu-Amara, Tova Volberg, Mukti Rao, Benjamin Geiger, Samuel I Stupp

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

The supramolecular design of bioactive artificial extracellular matrices to control cell behavior is of critical importance in cell therapies and cell assays. Most previous work in this area has focused on polymers or monolayers which preclude control of signal density and accessibility in the nanoscale filamentous environment of natural matrices. We have used here self-assembling supramolecular nanofibers that display the cell adhesion ligand RGDS at van der Waals density to cells. Signal accessibility at this very high density has been varied by changes in molecular architecture and therefore through the supramolecular packing of monomers that form the fibers. We found that branched architectures of the monomers and the consequent lower packing efficiency and additional space for epitope motion improves signaling for cell adhesion, spreading, and migration. The use of artificial matrices with nanoscale objects with extremely high epitope densities could facilitate receptor clustering for signaling and also maximize successful binding between ligands and receptors at mobile three-dimensional interfaces between matrices and cells. Supramolecular design of artificial bioactive extracellular matrices to tune cell response may prove to be a powerful strategy in regenerative medicine and to study biological processes.

Original languageEnglish
Pages (from-to)4608-4618
Number of pages11
JournalBiomaterials
Volume28
Issue number31
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Epitopes
Cell adhesion
Cell Adhesion
Monomers
Ligands
Nanofibers
Extracellular Matrix
Monolayers
Assays
Polymers
Biological Phenomena
Behavior Control
Regenerative Medicine
Fibers
Cell- and Tissue-Based Therapy
Cell Movement
Cluster Analysis
Cell Count

Keywords

  • Cell adhesion
  • Cell signaling
  • Hydrogel
  • Self-assembly

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Storrie, H., Guler, M. O., Abu-Amara, S. N., Volberg, T., Rao, M., Geiger, B., & Stupp, S. I. (2007). Supramolecular crafting of cell adhesion. Biomaterials, 28(31), 4608-4618. https://doi.org/10.1016/j.biomaterials.2007.06.026

Supramolecular crafting of cell adhesion. / Storrie, Hannah; Guler, Mustafa O.; Abu-Amara, Suha N.; Volberg, Tova; Rao, Mukti; Geiger, Benjamin; Stupp, Samuel I.

In: Biomaterials, Vol. 28, No. 31, 11.2007, p. 4608-4618.

Research output: Contribution to journalArticle

Storrie, H, Guler, MO, Abu-Amara, SN, Volberg, T, Rao, M, Geiger, B & Stupp, SI 2007, 'Supramolecular crafting of cell adhesion', Biomaterials, vol. 28, no. 31, pp. 4608-4618. https://doi.org/10.1016/j.biomaterials.2007.06.026
Storrie H, Guler MO, Abu-Amara SN, Volberg T, Rao M, Geiger B et al. Supramolecular crafting of cell adhesion. Biomaterials. 2007 Nov;28(31):4608-4618. https://doi.org/10.1016/j.biomaterials.2007.06.026
Storrie, Hannah ; Guler, Mustafa O. ; Abu-Amara, Suha N. ; Volberg, Tova ; Rao, Mukti ; Geiger, Benjamin ; Stupp, Samuel I. / Supramolecular crafting of cell adhesion. In: Biomaterials. 2007 ; Vol. 28, No. 31. pp. 4608-4618.
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